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Ouabain

RTECS #: RN3675000

CAS #: 630-60-4

UPDATE: February 2009 MW: 584.73 MF: C29H44O12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Acocantherin
  2. Astrobain
  3. G - Strophanthin
  4. Gratibain
  5. Gratus strophanthin
  6. Ouabagenin - L - rhamnosid (German)
  1. Ouabagenin L - rhamnoside
  2. Ouabaine
  3. Oubain
  4. Purostrophan
  5. Strophanthin G
  6. Strophoperm


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human lung 10 nmol/L CRNGDP 9,2245,1988
mutation in mammalian somatic cells mouse lymphocyte 513 µmol/L MUTAEX 3,193,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
guinea pig 		lowest published lethal dose: 40 µg/kg N/R AEPPAE 131,171,1928
intracerebral
mouse 		lethal dose (50 percent kill): 69 µg/kg Behavioral: Convulsions or effect on seizure threshold PLRCAT 6,417,1974
intraduodenal
cat 		lowest published lethal dose: 820 µg/kg N/R ARZNAD 8,557,1958
intraduodenal
guinea pig 		lethal dose (95 percent kill): 3,340 µg/kg N/R ARZNAD 8,557,1958
intramuscular
guinea pig 		lowest published lethal dose: 220 µg/kg N/R JPETAB 52,1,1934
intramuscular
pigeon 		lowest published lethal dose: 330 µg/kg N/R COREAF 149,306,1909
intramuscular
rabbit 		lowest published lethal dose: 1 mg/kg N/R COREAF 149,306,1909
intraperitoneal
cat 		lethal dose (50 percent kill): 100 µg/kg N/R AIPTAK 155,165,1965
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 210 µg/kg N/R ABMGAJ 12,434,1964
intraperitoneal
mouse 		lethal dose (50 percent kill): 11 mg/kg N/R AIPTAK 155,165,1965
intravenous
cat 		lethal dose (50 percent kill): 100 µg/kg N/R PSEBAA 35,316,1936
intravenous
cat 		lowest published toxic dose: 0.11 mg/kg Cardiac: Other changes

Vascular: BP elevation not characterized in autonomic section

Vascular: Measurement of regional blood flow 		CEXPB9 28,510,2001
intravenous
dog 		lowest published lethal dose: 54 µg/kg Cardiac: Change in rate JPETAB 179,447,1971
intravenous
dog 		lowest published toxic dose: 109 µg/kg/3 hour Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Pulse rate increased without fall in BP

Cardiac: Change in force of contraction 		AACRAT 49,23,1970
intravenous
dog 		lethal dose (50 percent kill): 129 µg/kg/3 hour N/R AACRAT 49,23,1970
intravenous
dog 		lowest published toxic dose: 0.1 mg/kg Gastrointestinal: Nausea or vomiting FATOAO 47,55,1984
intravenous
frog 		lethal dose (50 percent kill): 250 µg/kg N/R NYKZAU 61,231,1965
intravenous
guinea pig 		lethal dose (50 percent kill): 228 µg/kg N/R ABMGAJ 12,434,1964
intravenous
guinea pig 		lowest published toxic dose: 0.3 mg/kg Cardiac: Arrythmias (indlucing changes in conduction) FATOAO 47,25,1984
intravenous
guinea pig 		lowest published toxic dose: 0.29 mg/kg Cardiac: Change in force of contraction EJPHAZ 580,224,2008
intravenous
guinea pig 		lowest published toxic dose: 88.6 µg/kg Cardiac: Cardiomyopathy including infarction

Cardiac: Arrythmias (indlucing changes in conduction)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases 		EJPHAZ 566,34,2007
intravenous
monkey 		lowest published lethal dose: 102 µg/kg N/R ARZNAD 13,412,1963
intravenous
mouse 		lethal dose (50 percent kill): 2,200 µg/kg N/R PSEBAA 118,756,1965
intravenous
pigeon 		lowest published lethal dose: 183 µg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Change in rate

Gastrointestinal: Nausea or vomiting 		AIPTAK 126,412,1960
intravenous
rat 		lethal dose (50 percent kill): 14 mg/kg N/R TXAPA9 20,44,1971
intravenous
rat 		lowest published toxic dose: 0.4 mg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Vascular: Measurement of regional blood flow 		EKFAE9 56,31,1993
intravenous
rabbit 		lethal dose (50 percent kill): 252 µg/kg N/R PLRCAT 13,571,1981
oral
cat 		lowest published lethal dose: 5 mg/kg N/R FARMA8 13,375,1953
oral
dog 		lowest published lethal dose: 1,500 µg/kg N/R HBAMAK 4,1289,1935
oral
guinea pig 		lethal dose (50 percent kill): 8,280 µg/kg N/R USXXAM #4230702
oral
mouse 		lethal dose (50 percent kill): 5 mg/kg N/R JJTOEX 4,105,1991
oral
pigeon 		lowest published lethal dose: 14 mg/kg N/R COREAF 149,306,1909
oral
rabbit 		lowest published lethal dose: 7 mg/kg N/R COREAF 149,306,1909
parenteral
frog 		lethal dose (50 percent kill): 370 µg/kg N/R NYKZAU 53,995,1957
subcutaneous
cat 		lowest published lethal dose: 150 µg/kg N/R ARZNAD 23,1125,1973
subcutaneous
dog 		lowest published lethal dose: 100 µg/kg N/R ARZNAD 23,1125,1973
subcutaneous
frog 		lowest published lethal dose: 400 µg/kg N/R ARZNAD 23,1125,1973
subcutaneous
guinea pig 		lowest published lethal dose: 100 µg/kg N/R ARZNAD 23,1125,1973
subcutaneous
mouse 		lethal dose (50 percent kill): 5 mg/kg N/R JJTOEX 4,105,1991
subcutaneous
rat 		lowest published lethal dose: 50 mg/kg N/R ARZNAD 23,1125,1973
subcutaneous
rabbit 		lowest published lethal dose: 100 µg/kg N/R ARZNAD 23,1125,1973
unreported route
cat 		lowest published lethal dose: 90 µg/kg N/R AIPTAK 148,471,1964
unreported route
rat 		lethal dose (50 percent kill): 125 mg/kg N/R TXAPA9 22,336,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 1.4 mg/kg/4 week- continuous Vascular: Contraction (isolated tissue) JCPCDT 35,538,2000
implant
rat 		lowest published toxic dose: 1,120 µg/kg/5 week- continuous Vascular: BP elevation not characterized in autonomic section

Vascular: Contraction (isolated tissue)

Vascular: Other changes 		BJPCBM 143,794,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
85ELDJ -,193,1963
TOXICOLOGY REVIEW
CHIMAD 5,93,1951
TOXICOLOGY REVIEW
TPHSDY 23,374,2002
TOXICOLOGY REVIEW
PHTOEH 93,105,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5303;
Number of Industries 1;
Total Number of Facilities 55;
Number of Occupations 4;
Total Number of Employees Exposed 8,551;
Total Number of Female Employees Exposed 7,627


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963
AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957-
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CHIMAD Chimia. (Postfach 2027, CH-4001 Basel, Switzerland) V.1- 1947-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
FARMA8 Farmacognosia. (Madrid, Spain) V.1-27, 1942-62. Discontinued.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JCPCDT Journal of Cardiovascular Pharmacology. (Raven Press, 1140 Ave. of the Americas, New York, NY 10036) V.1- 1979-
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as a cardiac stimulant

RTECS Compound Description:
   Drug
   Mutagen
   Human Data
   Natural Product

ALT CAS #: 36-06-6
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