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Oils, nutmeg

RTECS #: RJ3694800

CAS #: 8008-45-5

UPDATE: November 2007 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Myristica oil
  2. Nutmeg oil
  1. Oil of nutmeg
  2. Oil of myristica


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 14,631,1976


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 20 mg/disc TOFOD5 8,91,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,400 mg/kg (40 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TOLED5 7,239,1981
oral
mouse 		lowest published toxic dose: 4 gm/kg (40 day male) Reproductive: Effects on newborn: Germ cell effects (in offspring) TOLED5 7,239,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
cat 		lowest published lethal dose: 10 mL/kg N/R JAMAAP 234,274,1975
oral
hamster 		lethal dose (50 percent kill): 6,000 mg/kg N/R ENTOX* -,276,2005
oral
mouse 		lethal dose (50 percent kill): 4,620 mg/kg N/R ENTOX* -,276,2005
oral
rat 		lethal dose (50 percent kill): 2,620 mg/kg Behavioral: Somnolence (general depressed activity) FCTXAV 14,631,1976
oral
rat 		lethal dose (50 percent kill): 2,600 mg/kg N/R ENTOX* -,276,2005
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R FCTXAV 14,631,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ENTOX* -,276,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5131;
Number of Industries 6;
Total Number of Facilities 758;
Number of Occupations 19;
Total Number of Employees Exposed 21,491;
Total Number of Female Employees Exposed 14,518


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
TOFOD5 Tokishikoroji Foramu. Toxicology Forum. (Saiensu Foramu, c/o Kida Bldg., 1-2-13 Yushima, Bunkyo-ku, Tokyo 113, Japan) V.6- 1983-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as a flavoring agent in food

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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