RTECS:RH6550000 The Registry of Toxic Effects of Chemical Substances

Octyl alcohol

RTECS #: RH6550000

CAS #: 111-87-5

UPDATE: February 2008 MW: 130.26 MF: C₈H₁₈O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1 - Hydroxyoctane

1 - Octanol

Alcohol C - 8

Alfol 8

Caprylic alcohol

Dytol M - 83

EPAL 8

Heptyl carbinol

Lorol 20

Octanol

Octilin

Octyl alcohol, normal - primary

Primary octyl alcohol

Sipol L8

n - Octanol

n - Octyl alcohol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
rabbit 500 mg/24 hour mild FCTXAV 11,1079,1973

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
sex chromosome loss and nondisjunction hamster lung 800 ľmol/L MUREAV 182,135,1987

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
human lowest published toxic concentration: 0.1 ppm/4 hour Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes NRTXDN 24,179,2003
inhalation
mouse lowest published toxic concentration: 4.5 gm/m³/2 hour N/R TPKVAL 5,51,1963
inhalation
rat lowest published lethal concentration: 5,600 mg/m³/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage EPASR* 8EHQ-1088-0762
intraperitoneal
rat lowest published toxic dose: 2,000 mg/kg Behavioral: Ataxia

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVGK* -,115,1984
intravenous
mouse lethal dose (50 percent kill): 69 mg/kg N/R AIPTAK 135,330,1962
ocular
rabbit lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 5,51,1963
oral
human lowest published lethal dose: 428.6 mg/kg N/R VCVGK* -,116,1984
oral
mouse lethal dose (50 percent kill): 1,790 mg/kg N/R HYSAAV 31(1-3),310,1966
oral
mouse lethal dose (50 percent kill): 15,000 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVGK* -,115,1984
oral
mouse lethal dose (50 percent kill): 3.91 gm/kg Brain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia TPKVAL 5,51,1963
oral
mouse lowest published lethal dose: 1.95 gm/kg Brain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia TPKVAL 5,51,1963
oral
rat lethal dose (50 percent kill): >3,200 mg/kg N/R FCTXAV 11,95,1973
oral
rat lethal dose (50 percent kill): 20,000 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVGK* -,115,1984
parenteral
frog lowest published lethal dose: 1,240 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity) AIPTAK 50,296,1935
skin
guinea pig lethal dose (50 percent kill): >1 gm/kg N/R FCTXAV 11,95,1973
skin
mouse lowest published lethal dose: 100 pph/3 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Corrosive TPKVAL 5,51,1963
skin
rabbit lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 5,51,1963
unreported route
mammal (species unspecified) lethal dose (50 percent kill): 4 gm/kg N/R GISAAA 51(5),61,1986

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 0.27 gm/m³/107 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 5,51,1963
inhalation
rat lowest published toxic concentration: 0.27 gm/m³/137 day- intermittent Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TPKVAL 5,51,1963

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 140-141,261,2003
TOXICOLOGY REVIEW
MUREAV 628,67,2007

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,292,1998
Occupational Exposure Limit - AUSTRIA MAK 106 mg/m³ (20 ppm), JAN 2006
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80235;
Number of Industries 29;
Total Number of Facilities 1,071;
Number of Occupations 32;
Total Number of Employees Exposed 13,905
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80235;
Number of Industries 133;
Total Number of Facilities 9,310;
Number of Occupations 93;
Total Number of Employees Exposed 287,737;
Total Number of Female Employees Exposed 72,792

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent, OCTYL CHLORIDE intermediate, specialty ethoxylate intermediate, defoamer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as solvent, OCTYL CHLORIDE intermediate, specialty ethoxylate intermediate, defoamer

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data
   Natural Product
   Primary Irritant

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SYNONYMS:
1 - Hydroxyoctane 1 - Octanol Alcohol C - 8 Alfol 8 Caprylic alcohol Dytol M - 83 EPAL 8 Heptyl carbinol	Lorol 20 Octanol Octilin Octyl alcohol, normal - primary Primary octyl alcohol Sipol L8 n - Octanol n - Octyl alcohol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin rabbit	500 mg/24 hour	mild	FCTXAV 11,1079,1973

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
sex chromosome loss and nondisjunction	hamster lung	800 ľmol/L	MUREAV 182,135,1987

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation human	lowest published toxic concentration: 0.1 ppm/4 hour	Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Other changes	NRTXDN 24,179,2003
inhalation mouse	lowest published toxic concentration: 4.5 gm/m³/2 hour	N/R	TPKVAL 5,51,1963
inhalation rat	lowest published lethal concentration: 5,600 mg/m³/4 hour	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Hemorrhage	EPASR* 8EHQ-1088-0762
intraperitoneal rat	lowest published toxic dose: 2,000 mg/kg	Behavioral: Ataxia Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,115,1984
intravenous mouse	lethal dose (50 percent kill): 69 mg/kg	N/R	AIPTAK 135,330,1962
ocular rabbit	lowest published toxic dose: 100 pph	Eye: Conjunctiva irritation	TPKVAL 5,51,1963
oral human	lowest published lethal dose: 428.6 mg/kg	N/R	VCVGK* -,116,1984
oral mouse	lethal dose (50 percent kill): 1,790 mg/kg	N/R	HYSAAV 31(1-3),310,1966
oral mouse	lethal dose (50 percent kill): 15,000 mg/kg	Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,115,1984
oral mouse	lethal dose (50 percent kill): 3.91 gm/kg	Brain and Coverings: Changes in circulation Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia	TPKVAL 5,51,1963
oral mouse	lowest published lethal dose: 1.95 gm/kg	Brain and Coverings: Changes in circulation Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia	TPKVAL 5,51,1963
oral rat	lethal dose (50 percent kill): >3,200 mg/kg	N/R	FCTXAV 11,95,1973
oral rat	lethal dose (50 percent kill): 20,000 mg/kg	Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,115,1984
parenteral frog	lowest published lethal dose: 1,240 mg/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity)	AIPTAK 50,296,1935
skin guinea pig	lethal dose (50 percent kill): >1 gm/kg	N/R	FCTXAV 11,95,1973
skin mouse	lowest published lethal dose: 100 pph/3 hour	Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Skin: After topical application: Corrosive	TPKVAL 5,51,1963
skin rabbit	lowest published toxic dose: 100 pph	Skin: After topical application: Primary irritation	TPKVAL 5,51,1963
unreported route mammal (species unspecified)	lethal dose (50 percent kill): 4 gm/kg	N/R	GISAAA 51(5),61,1986

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 0.27 gm/m³/107 day- intermittent	Peripheral Nerve and Sensation: Recording from peripheral motor nerve	TPKVAL 5,51,1963
inhalation rat	lowest published toxic concentration: 0.27 gm/m³/137 day- intermittent	Brain and Coverings: Changes in circulation Lung, Thorax, or Respiration: Emphysema Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	TPKVAL 5,51,1963

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		TOLED5 140-141,261,2003
TOXICOLOGY REVIEW		MUREAV 628,67,2007

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988	PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION	FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF	PESTICIDES: Cancelled	RBREV* -,292,1998
Occupational Exposure Limit - AUSTRIA	MAK 106 mg/m³ (20 ppm), JAN 2006
Occupational Exposure Limit - RUSSIA	short term exposure limit 10 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 80235; Number of Industries 29; Total Number of Facilities 1,071; Number of Occupations 32; Total Number of Employees Exposed 13,905
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 80235; Number of Industries 133; Total Number of Facilities 9,310; Number of Occupations 93; Total Number of Employees Exposed 287,737; Total Number of Female Employees Exposed 72,792

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent, OCTYL CHLORIDE intermediate, specialty ethoxylate intermediate, defoamer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AIPTAK	Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
EPASR*	United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA	Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV	Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN	Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
RBREV*	Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.