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D - erythro - D - galacto - Octopyranoside, methyl 6,8 - dideoxy - 6 - (1 - methyl - 4 - propyl - L - 2 - pyrrolidinecarboxamido) - 1 - thio - , monohydrochloride, trans - alpha -

RTECS #: RH6315000

CAS #: 859-18-7

UPDATE: February 2006 MW: 443.06 MF: C18H34N2O6S•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. Lincocin
  2. Lincomycin hydrochloride
  1. U 10149a


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN -,1260,1990
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 732 mg/kg N/R BFPHA8 18,131,1979
intraperitoneal
mouse 		lethal dose (50 percent kill): 750 mg/kg N/R BFPHA8 18,131,1979
intravenous
mouse 		lethal dose (50 percent kill): 214 mg/kg N/R TXAPA9 6,476,1964
intravenous
rat 		lethal dose (50 percent kill): 342 mg/kg N/R TXAPA9 6,476,1964
oral
dog 		lethal dose : >300 mg/kg N/R TXAPA9 6,476,1964
oral
monkey 		lethal dose : >300 mg/kg N/R TXAPA9 6,476,1964
oral
mouse 		lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN -,1260,1990
oral
rat 		lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN -,1260,1990
subcutaneous
mouse 		lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN -,1260,1990
subcutaneous
rat 		lethal dose (50 percent kill): 9,778 mg/kg N/R TXAPA9 9,445,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Gastrointestinal: Hypermotility, diarrhea

Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BFPHA8 18,131,1979
oral
rat 		lowest published toxic dose: 109,200 mg/kg/52 week- continuous Kidney, Ureter, and Bladder: Other changes TXAPA9 6,476,1964


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4977;
Number of Industries 3;
Total Number of Facilities 808;
Number of Occupations 14;
Total Number of Employees Exposed 20,887;
Total Number of Female Employees Exposed 10,760


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
BFPHA8 Bulletin of the Faculty of Pharmacy (Cairo University). (Faculty of Pharmacy, Cairo Univ., Cairo, Egypt) V.1- 1961/62-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an antibiotic

RTECS Compound Description:
   Drug

ALT CAS #: 59112-35-5
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