RTECS:RH6300000 The Registry of Toxic Effects of Chemical Substances

L - threo - D - galacto - Octopyranoside, methyl 7 - chloro - 6,7,8 - trideoxy - 6 - (1 - methyl - 4 - propyl - L - 2 - pyrrolidinecarboxamido) - 1 - thio - , trans - alpha -

RTECS #: RH6300000

CAS #: 18323-44-9

UPDATE: May 2009 MW: 425.04 MF: C₁₈H₃₃ClN₂O₅S

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

7 (S) - Chloro - 7 - deoxylincomycin

7 - CDL

7 - Chlorodeoxylincomycin

7 - Chlorolincomycin

Chlolincocin

Cleocin

Clindamycin

Clindamycine (French)

Clinimycin

Dalacin C

Sobelin

U - 21,251

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
mouse lethal dose (50 percent kill): 1,100 mg/kg N/R VCVPS* -,408,1998
intramuscular
rat lethal dose (50 percent kill): 3,500 mg/kg N/R VCVPS* -,408,1998
intraperitoneal
mammal (species unspecified) lethal dose (50 percent kill): 262 mg/kg N/R VCVPS* -,408,1998
intraperitoneal
mouse lethal dose (50 percent kill): 361 mg/kg N/R VCVPS* -,408,1998
intraperitoneal
rat lethal dose (50 percent kill): 745 mg/kg N/R VCVPS* -,408,1998
intravenous
mammal (species unspecified) lethal dose (50 percent kill): 143 mg/kg N/R VCVPS* -,408,1998
intravenous
mouse lethal dose (50 percent kill): 245 mg/kg N/R VCVPS* -,408,1998
intravenous
rabbit lowest published toxic dose: 5 mg/kg Vascular: BP lowering not characterized in autonomic section VCVPS* -,408,1998
oral
hamster lowest published lethal dose: 1 mg/kg Gastrointestinal: Other changes ARZNAD 34,794,1984
oral
mammal (species unspecified) lethal dose (50 percent kill): 5,000 mg/kg N/R VCVPS* -,408,1998
oral
mouse lethal dose (50 percent kill): 2,540 mg/kg N/R VCVPS* -,408,1998
oral
rat lethal dose (50 percent kill): 2,190 mg/kg N/R VCVPS* -,408,1998
oral
rabbit lowest published lethal dose: 1 mg/kg N/R RMVEAG 156,915,1980
subcutaneous
rat lethal dose (50 percent kill): 2,618 mg/kg N/R TXAPA9 18,185,1971

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
human lowest published toxic dose: 89.6 mg/kg/7 day- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting VCVPS* -,408,1998
oral
human lowest published toxic dose: 60.2 mg/kg/7 day- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes VCVPS* -,409,1998
oral
human lowest published toxic dose: 90 mg/kg/7 day- intermittent Skin: After systemic exposure: Dermatitis, allergic BJDEAZ 146,643,2002
oral
rat lowest published toxic dose: 4,200 mg/kg/2 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases VCVPS* -,408,1998
oral
rat lowest published toxic dose: 210 mg/kg/3 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases VCVPS* -,408,1998
oral
rat lowest published toxic dose: 210 mg/kg/3 week- intermittent Blood: Change in clotting factors VCVPS* -,408,1998
oral
rabbit lowest published toxic dose: 330 mg/kg/33 day- intermittent Gastrointestinal: Other changes ANTBAL 28,18,1983

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TOLED5 142,207,2003
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
HPCQA4 38,527,2007

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3191;
Number of Industries 1;
Total Number of Facilities 445;
Number of Occupations 7;
Total Number of Employees Exposed 21,575;
Total Number of Female Employees Exposed 17,442

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
HPCQA4 Human Pathology. (W.B. Saunders Co., W. Washington Sq., Philadelphia, PA 19105) V.1- 1970-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year Book Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

RTECS Compound Description:
   Drug
   Human Data
   Natural Product

Click Here for Additional Information about RTECS

NIOSH Home | NIOSH Search | Site Index | Topic List | Contact Us

SYNONYMS:
7 (S) - Chloro - 7 - deoxylincomycin 7 - CDL 7 - Chlorodeoxylincomycin 7 - Chlorolincomycin Chlolincocin Cleocin	Clindamycin Clindamycine (French) Clinimycin Dalacin C Sobelin U - 21,251

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular mouse	lethal dose (50 percent kill): 1,100 mg/kg	N/R	VCVPS* -,408,1998
intramuscular rat	lethal dose (50 percent kill): 3,500 mg/kg	N/R	VCVPS* -,408,1998
intraperitoneal mammal (species unspecified)	lethal dose (50 percent kill): 262 mg/kg	N/R	VCVPS* -,408,1998
intraperitoneal mouse	lethal dose (50 percent kill): 361 mg/kg	N/R	VCVPS* -,408,1998
intraperitoneal rat	lethal dose (50 percent kill): 745 mg/kg	N/R	VCVPS* -,408,1998
intravenous mammal (species unspecified)	lethal dose (50 percent kill): 143 mg/kg	N/R	VCVPS* -,408,1998
intravenous mouse	lethal dose (50 percent kill): 245 mg/kg	N/R	VCVPS* -,408,1998
intravenous rabbit	lowest published toxic dose: 5 mg/kg	Vascular: BP lowering not characterized in autonomic section	VCVPS* -,408,1998
oral hamster	lowest published lethal dose: 1 mg/kg	Gastrointestinal: Other changes	ARZNAD 34,794,1984
oral mammal (species unspecified)	lethal dose (50 percent kill): 5,000 mg/kg	N/R	VCVPS* -,408,1998
oral mouse	lethal dose (50 percent kill): 2,540 mg/kg	N/R	VCVPS* -,408,1998
oral rat	lethal dose (50 percent kill): 2,190 mg/kg	N/R	VCVPS* -,408,1998
oral rabbit	lowest published lethal dose: 1 mg/kg	N/R	RMVEAG 156,915,1980
subcutaneous rat	lethal dose (50 percent kill): 2,618 mg/kg	N/R	TXAPA9 18,185,1971

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral human	lowest published toxic dose: 89.6 mg/kg/7 day- intermittent	Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting	VCVPS* -,408,1998
oral human	lowest published toxic dose: 60.2 mg/kg/7 day- intermittent	Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Other changes	VCVPS* -,409,1998
oral human	lowest published toxic dose: 90 mg/kg/7 day- intermittent	Skin: After systemic exposure: Dermatitis, allergic	BJDEAZ 146,643,2002
oral rat	lowest published toxic dose: 4,200 mg/kg/2 week- intermittent	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	VCVPS* -,408,1998
oral rat	lowest published toxic dose: 210 mg/kg/3 week- intermittent	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	VCVPS* -,408,1998
oral rat	lowest published toxic dose: 210 mg/kg/3 week- intermittent	Blood: Change in clotting factors	VCVPS* -,408,1998
oral rabbit	lowest published toxic dose: 330 mg/kg/33 day- intermittent	Gastrointestinal: Other changes	ANTBAL 28,18,1983

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		MUREAV 488,151,2001
TOXICOLOGY REVIEW		TOLED5 142,207,2003
TOXICOLOGY REVIEW		EMMUEG 43,143,2004
TOXICOLOGY REVIEW		EJIME* 17,529,2006
TOXICOLOGY REVIEW		DIMON* 39,678,1993
TOXICOLOGY REVIEW		HPCQA4 38,527,2007

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X3191; Number of Industries 1; Total Number of Facilities 445; Number of Occupations 7; Total Number of Employees Exposed 21,575; Total Number of Female Employees Exposed 17,442

REFERENCES:
CODEN	REFERENCE
ANTBAL	Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
ARZNAD	Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJDEAZ	British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
DIMON*	Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJIME*	European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
EMMUEG	Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
HPCQA4	Human Pathology. (W.B. Saunders Co., W. Washington Sq., Philadelphia, PA 19105) V.1- 1970-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RMVEAG	Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year Book Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824-
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS*	"Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.