RTECS:RH3400000 The Registry of Toxic Effects of Chemical Substances

6 - Octen - 1 - ol, 3,7 - dimethyl -

RTECS #: RH3400000

CAS #: 106-22-9

UPDATE: May 2009 MW: 156.30 MF: C₁₀H₂₀O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,6 - Dimethyl - 2 - octen - 8 - ol

3,7 - Dimethyl - 6 - octen - 1 - ol

Cephrol

Citronellol

Rhodinol

Rodinol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 0.42% moderate FEREAC 69,23142,2004
skin
guinea pig 100 mg/24 hour severe CTOIDG 94(8),41,1979
skin
man 16 mg/48 hour moderate CTOIDG 94(8),41,1979
skin
rabbit 100 mg/24 hour severe CTOIDG 94(8),41,1979
skin
rabbit 0.42%/4 hour moderate FEREAC 69,23142,2004

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 1.3 mg/m³/4 hour N/R VCVPS* -,289,1998
inhalation
rat lowest published toxic concentration: 1.3 mg/m³/4 hour Behavioral: Alteration of classical conditioning VCVPS* -,289,1998
intramuscular
mouse lethal dose (50 percent kill): 4 gm/kg N/R JSICAZ 21,342,1962
intraperitoneal
mouse lowest published toxic dose: 100 mg/kg Behavioral: Antianxiety LIFSAK 72,91,2002
oral
rat lethal dose (50 percent kill): 3,450 mg/kg N/R FCTXAV 13,757,1975
oral
rat lethal dose (50 percent kill): 5 gm/kg Brain and Coverings: Other degenerative changes

Skin: After systemic exposure: Dermatitis, other VCVPS* -,289,1998
oral
rat lowest published toxic dose: 5 gm/kg Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight VCVPS* -,289,1998
subcutaneous
mouse lethal dose (50 percent kill): 880 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change SIZSAR 3,73,1952
skin
rabbit lethal dose (50 percent kill): 2,650 mg/kg N/R FCTXAV 13,757,1975

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 0.3 mg/m³/4 hour/3 day- intermittent Behavioral: Alteration of classical conditioning VCVPS* -,289,1998
inhalation
rat lowest published toxic concentration: 2.8 mg/m³/24 hour/100 day- continuous Olfaction: Change in sensation of smell

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase VCVPS* -,289,1998

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FCTOD7 46,S1,2008

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1604;
Number of Industries 4;
Total Number of Facilities 63;
Number of Occupations 35;
Total Number of Employees Exposed 7,418
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1604;
Number of Industries 62;
Total Number of Facilities 8,621;
Number of Occupations 83;
Total Number of Employees Exposed 163,706;
Total Number of Female Employees Exposed 87,309

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as fragrance raw materials

RTECS Compound Description:
   Agricultural Chemical
   Human Data
   Natural Product
   Primary Irritant

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SYNONYMS:
2,6 - Dimethyl - 2 - octen - 8 - ol 3,7 - Dimethyl - 6 - octen - 1 - ol Cephrol	Citronellol Rhodinol Rodinol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye rabbit	0.42%	moderate	FEREAC 69,23142,2004
skin guinea pig	100 mg/24 hour	severe	CTOIDG 94(8),41,1979
skin man	16 mg/48 hour	moderate	CTOIDG 94(8),41,1979
skin rabbit	100 mg/24 hour	severe	CTOIDG 94(8),41,1979
skin rabbit	0.42%/4 hour	moderate	FEREAC 69,23142,2004

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 1.3 mg/m³/4 hour	N/R	VCVPS* -,289,1998
inhalation rat	lowest published toxic concentration: 1.3 mg/m³/4 hour	Behavioral: Alteration of classical conditioning	VCVPS* -,289,1998
intramuscular mouse	lethal dose (50 percent kill): 4 gm/kg	N/R	JSICAZ 21,342,1962
intraperitoneal mouse	lowest published toxic dose: 100 mg/kg	Behavioral: Antianxiety	LIFSAK 72,91,2002
oral rat	lethal dose (50 percent kill): 3,450 mg/kg	N/R	FCTXAV 13,757,1975
oral rat	lethal dose (50 percent kill): 5 gm/kg	Brain and Coverings: Other degenerative changes Skin: After systemic exposure: Dermatitis, other	VCVPS* -,289,1998
oral rat	lowest published toxic dose: 5 gm/kg	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	VCVPS* -,289,1998
subcutaneous mouse	lethal dose (50 percent kill): 880 mg/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change	SIZSAR 3,73,1952
skin rabbit	lethal dose (50 percent kill): 2,650 mg/kg	N/R	FCTXAV 13,757,1975

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 0.3 mg/m³/4 hour/3 day- intermittent	Behavioral: Alteration of classical conditioning	VCVPS* -,289,1998
inhalation rat	lowest published toxic concentration: 2.8 mg/m³/24 hour/100 day- continuous	Olfaction: Change in sensation of smell Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	VCVPS* -,289,1998

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		FCTOD7 46,S1,2008

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: A1604; Number of Industries 4; Total Number of Facilities 63; Number of Occupations 35; Total Number of Employees Exposed 7,418
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: A1604; Number of Industries 62; Total Number of Facilities 8,621; Number of Occupations 83; Total Number of Employees Exposed 163,706; Total Number of Female Employees Exposed 87,309

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
CTOIDG	Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
FCTOD7	Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JSICAZ	Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
LIFSAK	Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
SIZSAR	Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952-
VCVPS*	"Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.