The Registry of Toxic Effects of Chemical Substances

2,6 - Octadien - 1 - ol, 3,7 - dimethyl - , (E) -

RTECS #: RG5830000

CAS #: 106-24-1

UPDATE: May 2008 MW: 154.28 MF: C10H18O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2,6 - Dimethyl - trans - 2,6 - octadien - 8 - ol
  2. 2,6 - Octadien - 1 - ol, 3,7 - dimethyl - , trans -
  3. 3,7 - Dimethyl - trans - 2,6 - octadien - 1 - ol
  4. Geraniol
  5. Geraniol alcohol
  1. Geraniol Extra
  2. Geranyl alcohol
  3. Guaniol
  4. Lemonol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
guinea pig 		100 mg/24 hour severe CTOIDG 94(8),41,1979
skin
man 		16 mg/24 hour severe CTOIDG 94(8),41,1979
skin
rabbit 		100 mg/24 hour severe CTOIDG 94(8),41,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 78.1 mg/L/3 hour (-enzymatic activation step) MUREAV 629,148,2007
cytogenetic analysis hamster ovary 39.1 mg/L/3 hour (+enzymatic activation step) MUREAV 629,148,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 0.5 mg/m3/4 hour N/R VCVPS* -,289,1998
inhalation
rat 		lowest published toxic concentration: 0.5 mg/m3/4 hour Olfaction: Change in sensation of smell VCVPS* -,289,1998
intramuscular
mouse 		lethal dose (50 percent kill): 4 gm/kg N/R JSICAZ 21,342,1962
intravenous
rabbit 		lowest published lethal dose: 50 mg/kg N/R NYKZAU 58,394,1962
oral
mouse 		lethal dose (50 percent kill): 3.5 gm/kg Olfaction: Change in sensation of smell VCVPS* -,289,1998
oral
rat 		lethal dose (50 percent kill): 3,600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Skin and Appendages: Other: Hair 		FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 2.1 gm/kg Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVPS* -,289,1998
oral
rat 		lethal dose (50 percent kill): 4.5 gm/kg N/R VCVPS* -,285,1998
subcutaneous
mouse 		lethal dose (50 percent kill): 1,090 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change SIZSAR 3,73,1952
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 12,881,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83197;
Number of Industries 6;
Total Number of Facilities 169;
Number of Occupations 40;
Total Number of Employees Exposed 10,861
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83197;
Number of Industries 82;
Total Number of Facilities 11,902;
Number of Occupations 88;
Total Number of Employees Exposed 192,214;
Total Number of Female Employees Exposed 104,351


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as fragrance raw materials

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data
   Natural Product
   Primary Irritant

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