RTECS:RG5830000 The Registry of Toxic Effects of Chemical Substances

2,6 - Octadien - 1 - ol, 3,7 - dimethyl - , (E) -

RTECS #: RG5830000

CAS #: 106-24-1

UPDATE: May 2009 MW: 154.28 MF: C₁₀H₁₈O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

ACUTE TOXICITY DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,6 - Dimethyl - trans - 2,6 - octadien - 8 - ol

2,6 - Octadien - 1 - ol, 3,7 - dimethyl - , trans -

3,7 - Dimethyl - trans - 2,6 - octadien - 1 - ol

Geraniol

Geraniol alcohol

Geraniol Extra

Geranyl alcohol

Guaniol

Lemonol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
guinea pig 100 mg/24 hour severe CTOIDG 94(8),41,1979
skin
man 16 mg/24 hour severe CTOIDG 94(8),41,1979
skin
rabbit 100 mg/24 hour severe CTOIDG 94(8),41,1979

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis hamster ovary 78.1 mg/L/3 hour (-enzymatic activation step) MUREAV 629,148,2007
cytogenetic analysis hamster ovary 39.1 mg/L/3 hour (+enzymatic activation step) MUREAV 629,148,2007

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 0.5 mg/m³/4 hour N/R VCVPS* -,289,1998
inhalation
rat lowest published toxic concentration: 0.5 mg/m³/4 hour Olfaction: Change in sensation of smell VCVPS* -,289,1998
intramuscular
mouse lethal dose (50 percent kill): 4 gm/kg N/R JSICAZ 21,342,1962
intravenous
rabbit lowest published lethal dose: 50 mg/kg N/R NYKZAU 58,394,1962
oral
mouse lethal dose (50 percent kill): 3.5 gm/kg Olfaction: Change in sensation of smell VCVPS* -,289,1998
oral
rat lethal dose (50 percent kill): 3,600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Skin and Appendages: Other: Hair FCTXAV 2,327,1964
oral
rat lethal dose (50 percent kill): 2.1 gm/kg Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight VCVPS* -,289,1998
oral
rat lethal dose (50 percent kill): 4.5 gm/kg N/R VCVPS* -,285,1998
subcutaneous
mouse lethal dose (50 percent kill): 1,090 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change SIZSAR 3,73,1952
skin
rabbit lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 12,881,1974

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FCTOD7 46,S1,2008

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83197;
Number of Industries 6;
Total Number of Facilities 169;
Number of Occupations 40;
Total Number of Employees Exposed 10,861
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83197;
Number of Industries 82;
Total Number of Facilities 11,902;
Number of Occupations 88;
Total Number of Employees Exposed 192,214;
Total Number of Female Employees Exposed 104,351

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as fragrance raw materials

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data
   Natural Product
   Primary Irritant

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SYNONYMS:
2,6 - Dimethyl - trans - 2,6 - octadien - 8 - ol 2,6 - Octadien - 1 - ol, 3,7 - dimethyl - , trans - 3,7 - Dimethyl - trans - 2,6 - octadien - 1 - ol Geraniol Geraniol alcohol	Geraniol Extra Geranyl alcohol Guaniol Lemonol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin guinea pig	100 mg/24 hour	severe	CTOIDG 94(8),41,1979
skin man	16 mg/24 hour	severe	CTOIDG 94(8),41,1979
skin rabbit	100 mg/24 hour	severe	CTOIDG 94(8),41,1979

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	hamster ovary	78.1 mg/L/3 hour (-enzymatic activation step)	MUREAV 629,148,2007
cytogenetic analysis	hamster ovary	39.1 mg/L/3 hour (+enzymatic activation step)	MUREAV 629,148,2007

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 0.5 mg/m³/4 hour	N/R	VCVPS* -,289,1998
inhalation rat	lowest published toxic concentration: 0.5 mg/m³/4 hour	Olfaction: Change in sensation of smell	VCVPS* -,289,1998
intramuscular mouse	lethal dose (50 percent kill): 4 gm/kg	N/R	JSICAZ 21,342,1962
intravenous rabbit	lowest published lethal dose: 50 mg/kg	N/R	NYKZAU 58,394,1962
oral mouse	lethal dose (50 percent kill): 3.5 gm/kg	Olfaction: Change in sensation of smell	VCVPS* -,289,1998
oral rat	lethal dose (50 percent kill): 3,600 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Coma Skin and Appendages: Other: Hair	FCTXAV 2,327,1964
oral rat	lethal dose (50 percent kill): 2.1 gm/kg	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	VCVPS* -,289,1998
oral rat	lethal dose (50 percent kill): 4.5 gm/kg	N/R	VCVPS* -,285,1998
subcutaneous mouse	lethal dose (50 percent kill): 1,090 mg/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change	SIZSAR 3,73,1952
skin rabbit	lethal dose (50 percent kill): >5 gm/kg	N/R	FCTXAV 12,881,1974

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		FCTOD7 46,S1,2008

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 83197; Number of Industries 6; Total Number of Facilities 169; Number of Occupations 40; Total Number of Employees Exposed 10,861
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 83197; Number of Industries 82; Total Number of Facilities 11,902; Number of Occupations 88; Total Number of Employees Exposed 192,214; Total Number of Female Employees Exposed 104,351

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
CTOIDG	Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
FCTOD7	Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JSICAZ	Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NYKZAU	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
SIZSAR	Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952-
VCVPS*	"Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.