The Registry of Toxic Effects of Chemical Substances

2,6 - Octadienal, 3,7 - dimethyl -

RTECS #: RG5075000

CAS #: 5392-40-5

UPDATE: February 2006 MW: 152.26 MF: C10H16O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3,7 - Dimethyl - 2,6 - octadienal
  2. Citral
  1. Lemsyn GB
  2. NCI - C56348


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
guinea pig 		1%/48 hour moderate JSCCA5 28,357,1977
skin
guinea pig 		100 mg/24 hour severe CTOIDG 94(8),41,1979
skin
human 		40 mg/24 hour mild FCTXAV 17,259,1979
skin
man 		16 mg/48 hour severe CTOIDG 94(8),41,1979
skin
pig 		50 mg/48 hour severe CTOIDG 94(8),41,1979
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,259,1979
skin
rabbit 		100 mg/24 hour severe CTOIDG 94(8),41,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 2,222 µg/disc OIGZDE 34,267,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 1,800 mg/kg (22 week prior to copulation) Reproductive: Maternal effects: Oogenesis

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		FCTXAV 18,547,1980
intraperitoneal
rat 		lowest published toxic dose: 1,800 mg/kg (6 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		JRPFA4 55,347,1979
intraperitoneal
rat 		lowest published toxic dose: 1,800 mg/kg (6 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Other postnatal measures or effects 		VCVPS* -,286,1998
oral
rat 		lowest published toxic dose: 1,250 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXCYAC 96,105,1995
oral
rat 		lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Other developmental abnormalities 		TXCYAC 96,105,1995
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death 		TXCYAC 96,105,1995
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Sex ratio 		TXCYAC 96,105,1995
skin
rat 		lowest published toxic dose: 28 gm/kg (60 day prior to copulation) Reproductive: Maternal effects: Oogenesis

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		FCTXAV 18,547,1980
skin
rat 		lowest published toxic dose: 46 gm/kg (14 week prior to copulation) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) FCTXAV 18,547,1980
skin
rat 		lowest published toxic dose: 46 gm/kg (14 week prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		JRPFA4 55,347,1979
skin
rat 		lowest published toxic dose: 27,600 mg/kg (60 day prior to copulation) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) JRPFA4 55,347,1979
skin
rat 		lowest published toxic dose: 27.6 gm/kg (60 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Other postnatal measures or effects 		VCVPS* -,286,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 460 mg/kg N/R JRPFA4 55,347,1979
oral
mouse 		lethal dose (50 percent kill): 6 gm/kg Tumorigenic: Active as anti-cancer agent BIJOAK 34,1196,1940
oral
mouse 		lethal dose (50 percent kill): 1.67 gm/kg N/R VCVPS* -,291,1998
oral
rat 		lethal dose (50 percent kill): 4,960 mg/kg Behavioral: Somnolence (general depressed activity) FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 3.45 gm/kg Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVPS* -,291,1998
skin
rabbit 		lethal dose (50 percent kill): 2,250 mg/kg N/R FCTOD7 25,505,1987


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 1,800 mg/kg/6 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Related to Chronic Data: Changes in ovarian weight 		VCVPS* -,291,1998
oral
mouse 		lowest published toxic dose: 14,952 mg/kg/14 day- intermittent Liver: Other changes

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FCTOD7 31,463,1993
oral
rat 		lowest published toxic dose: 24 gm/kg/10 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Effect on specific coenzyme: CoA 		FCTOD7 25,505,1987
oral
rabbit 		lowest published toxic dose: 255 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Proteinuria

Blood: Other changes 		FAONAU 44A,1,1967
skin
mouse 		lowest published toxic dose: 525 mg/kg/3 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Increase in humoral response 		TXCYAC 206,285,2005
skin
rat 		lowest published toxic dose: 5,550 mg/kg/30 day- intermittent Endocrine: Other changes CBPCEE 115,169,1996
skin
rat 		lowest published toxic dose: 27.6 gm/kg/60 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Related to Chronic Data: Changes in ovarian weight 		VCVPS* -,291,1998
skin
rat 		lowest published toxic dose: 12,648 mg/kg/17 week- intermittent Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair 		URLRA5 20,139,1992
skin
rat 		lowest published toxic dose: 3,720 mg/kg/5 week- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands URLRA5 20,139,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83184;
Number of Industries 5;
Total Number of Facilities 353;
Number of Occupations 33;
Total Number of Employees Exposed 68,051
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83184;
Number of Industries 98;
Total Number of Facilities 12,505;
Number of Occupations 84;
Total Number of Employees Exposed 200,484;
Total Number of Female Employees Exposed 83,180


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as raw material for vitamin production and fragrance raw material precursor
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9204
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.74- 1983-
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
URLRA5 Urological Research. (Springer Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1973-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as raw material for vitamin production and fragrance raw material precursor

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product
   Primary Irritant

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