RTECS:RD5425000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

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Novobiocin, monosodium salt

RTECS #: RD5425000

CAS #: 1476-53-5

UPDATE: April 1999 MW: 634.67 MF: C₃₁H₃₅N₂O₁₁•Na

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

Albamycin (capsule)

Albamycin sodium

Cathomycin sodium

Cathomycin sodium lyovac

Monosodium novobiocin

Novobiocin monosodium

Novobiocin sodium

Novobiocin, sodium deriv.

Sodium albamycin

Sodium novobiocin

U - 6591

Vulcamycin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
DNA inhibition rat other cell types 1,400 mg/L ARTODN 60,287,1987
DNA inhibition rat other cell types 1 gm/L ARTODN 60,287,1987
unscheduled DNA synthesis rat other cell types 450 mg/L ARTODN 60,287,1987

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
guinea pig lethal dose (50 percent kill): 12 mg/kg N/R UPJOH* 2(6),-,1971
intraperitoneal
mouse lethal dose (50 percent kill): 262 mg/kg N/R ANTCAO 6,226,1956
intravenous
mouse lethal dose (50 percent kill): 407 mg/kg N/R ANTCAO 6,226,1956
intravenous
rat lethal dose (50 percent kill): 385 mg/kg N/R ARZNAD 8,386,1958
oral
mouse lethal dose (50 percent kill): 962 mg/kg N/R ANTCAO 6,226,1956
oral
rat lethal dose (50 percent kill): 3,500 mg/kg N/R ARZNAD 8,386,1958
subcutaneous
guinea pig lethal dose (50 percent kill): 28 mg/kg N/R UPJOH* 2(6),-,1971
subcutaneous
mouse lethal dose (50 percent kill): 395 mg/kg N/R ARZNAD 8,386,1958
subcutaneous
rat lethal dose (50 percent kill): 450 mg/kg N/R ARZNAD 8,386,1958

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
subcutaneous
cat lowest published toxic dose: 3,920 mg/kg/70 day- intermittent Skin: After systemic exposure: Dermatitis, other ANTCAO 6,226,1956

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1522;
Number of Industries 1;
Total Number of Facilities 15;
Number of Occupations 1;
Total Number of Employees Exposed 88;
Total Number of Female Employees Exposed 73

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001)

FDA-proprietary drug

RTECS Compound Description:
Drug
Mutagen

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