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5 - Norbornene - 2,3 - dicarboxylic acid, 1,4,5,6,7,7 - hexachloro -

RTECS #: RB9000000

CAS #: 115-28-6

UPDATE: November 2007 MW: 388.83 MF: C9H4Cl6O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,4,5,6,7,7 - Hexachlorobicyclo (2.2.1) - 5 - heptene - 2,3 - dicarboxylic acid
  2. 1,4,5,6,7,7 - Hexachloro - 5 - norbornene - 2,3 - dicarboxylic acid
  3. Bicyclo (2.2.1) hept - 5 - ene - 2,3 - dicarboxylic acid, 1,4,5,6,7,7 - hexachloro - (9CI)
  4. Chlorendic acid
  5. HET acid
  1. Hexachloro - endo - methylenetetrahydrophthalic acid
  2. Kyselina 3,6 - endomethylen - 3,4,5,6,7,7 - hexachlor - delta (sup 4) - tetrahydroftalova (Czech)
  3. Kyselina 1,2,3,4,7,7 - hexachlorbicyklo (2,2,1) hept - 2 - en - 5,6 - dikarboxylova (Czech)
  4. NCI - C55072


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg/24 hour severe 85JCAE -,581,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,581,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 975 mg/L MUREAV 369,243,1996
mutation in mammalian somatic cells mouse lymphocyte 1,700 mg/L NTPTR* NTP-TR-304,1987
morphological transform mouse fibroblast 0.5 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
specific locus test mouse other cell types 2,000 mg/L/24 hour (-enzymatic activation step) MUTAEX 14,23,1999


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 108 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-304,1987
oral
mouse 		lowest published toxic dose: 64,169 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB87-206835/AS
oral
rat 		lowest published toxic dose: 45,063 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-304,1987
oral
rat 		lowest published toxic dose: 19,467 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		NTIS** PB87-206835/AS
oral
rat 		lowest published toxic dose: 47,586 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB87-206835/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >790 mg/m3/4 hour N/R NTIS** OTS0537100
oral
rat 		lethal dose : >1 gm/kg N/R NTIS** OTS0535786


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 84 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-304,1987
oral
mouse 		lowest published toxic dose: 218 gm/kg/13 week- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-304,1987
oral
mouse 		lowest published toxic dose: 2.0832 gm/kg/28 day- continuous Liver: Other changes EVHPAZ 110,363,2002
oral
mouse 		lowest published toxic dose: 6.696 gm/kg/90 day- continuous Liver: Other changes EVHPAZ 110,363,2002
oral
rat 		lowest published toxic dose: 35 gm/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-304,1987
oral
rat 		lowest published toxic dose: 45,500 mg/kg/13 week- continuous Liver: Other changes NTPTR* NTP-TR-304,1987
oral
rat 		lowest published toxic dose: 3.348 gm/kg/90 day- continuous Liver: Other changes EVHPAZ 110,363,2002
oral
rat 		lowest published toxic dose: 1.75 gm/kg/28 day- continuous Liver: Other changes EVHPAZ 110,363,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 48,45,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 48,45,1990
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUTAEX 14,5,1999
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0695;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 2;
Total Number of Employees Exposed 166
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0695;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 55;
Total Number of Female Employees Exposed 29


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in the preparation of fire-retardant polyester resins and plasticizers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used in the preparation of fire-retardant polyester resins and plasticizers

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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