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Nitrogen trifluoride

RTECS #: QX1925000

CAS #: 7783-54-2

UPDATE: May 2009 MW: 71.01 MF: F3N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Nitrogen fluoride (NF3)
  2. Nitrogen trifluoride (ACGIH:OSHA)
  1. Perfluoroammonia
  2. Trifluoroammonia


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration (50 percent kill): 9,600 ppm/1 hour Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia 		AMRL** TR-69-84,1969
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 200 mg/m3 Blood: Other changes

Blood: Changes in erythrocyte (RBC) count 		TOVEFN (2),37,2001
inhalation
monkey 		lethal concentration (50 percent kill): 7,500 ppm/1 hour Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia 		AMRL** TR-69-84,1969
inhalation
mouse 		lethal concentration (50 percent kill): 2,000 ppm/4 hour N/R 34ZIAG -,427,1969
inhalation
rat 		lethal concentration (50 percent kill): 6,700 ppm/1 hour Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory stimulation 		TXAPA9 26,1,1973
inhalation
rat 		lethal concentration (50 percent kill): 7,900 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (2),37,2001
inhalation
rat 		lethal concentration (16 percent kill): 4,250 mg/m3 Vascular: Other changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		TOVEFN (2),37,2001
inhalation
rat 		lethal concentration (16 percent kill): 4,250 mg/m3 Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition 		TOVEFN (2),37,2001
inhalation
rat 		lethal concentration (16 percent kill): 4,250 mg/m3 Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Other 		TOVEFN (2),37,2001
intraperitoneal
rat 		lethal dose (50 percent kill): 26 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia TXAPA9 17,585,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic dose: 100 ppm/7 hour/19 week- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Interstitial nephritis

Blood: Changes in spleen 		TXAPA9 4,770,1962
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour/2 week- intermittent Blood: Normocytic anemia NTIS** OTS0559285
inhalation
rat 		lowest published toxic concentration: 98.7 mg/m3/122 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Liver: Other changes 		TOVEFN (2),37,2001
inhalation
rat 		lowest published toxic concentration: 98.7 mg/m3/122 day- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes 		TOVEFN (2),37,2001
inhalation
rat 		lowest published toxic concentration: 98.7 mg/m3/122 day- intermittent Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Effect on mitochondrial function 		TOVEFN (2),37,2001
inhalation
rat 		lowest published toxic concentration: 10.2 mg/m3/182 day- intermittent Cardiac: Other changes

Liver: Other changes

Blood: Other changes 		TOVEFN (2),37,2001
inhalation
rat 		lowest published toxic concentration: 10.2 mg/m3/182 day- intermittent Blood: Changes in erythrocyte (RBC) count TOVEFN (2),37,2001
inhalation
rat 		lowest published toxic concentration: 1.18 mg/m3/182 day- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		TOVEFN (2),37,2001
inhalation
rat 		lowest published toxic concentration: 1.18 mg/m3/182 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		TOVEFN (2),37,2001
intraperitoneal
rabbit 		lowest published toxic dose: 85 gm/kg/29 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		TXAPA9 4,770,1962


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (29 mg/m3) DTLVS* 3,187,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (29 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (29 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (29 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (29 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (29 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (29 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (29 mg/m3), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2.5 mg(F)/m3, FEB 2006
Occupational Exposure Limit - FRANCE VME 10 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg(F)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (30 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (30 mg/m3);
short term exposure limit 15 ppm (45 mg/m3), 2004
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 29 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (29 mg/m3), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit - RUSSIA time-weighted average 30 mg/m3, short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (30 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROGEN TRIFLUORIDE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50885;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50885;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,096;
Total Number of Female Employees Exposed 140


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in chemical synthesis and as an oxidizer for high-energy fuels
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in chemical synthesis and as an oxidizer for high-energy fuels

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