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Nitric acid, uranium salt

RTECS #: QV2300000

CAS #: 15905-86-9

UPDATE: February 2009 MW: 1,729.02 MF: HNO3•xU


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. Uranium nitrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,029 mg/kg (91 day male/91 day prior to copulation-3 week after birth) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects 		NRTXDN 28,108,2007


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 2 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		NYKZAU 55,315,1959
intraperitoneal
rat 		lowest published lethal dose: 100 mg/kg N/R NJMSAG 24,133,1961
intravenous
mouse 		lethal dose (50 percent kill): 49 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		NYKZAU 55,315,1959
intravenous
rabbit 		lowest published lethal dose: 10 mg/kg Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory stimulation 		NYKZAU 55,315,1959
subcutaneous
dog 		lowest published lethal dose: 2 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes 		AJMSA9 178,449,1929
subcutaneous
guinea pig 		lowest published lethal dose: 10 mg/kg Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AIMDAP 3,375,1909
subcutaneous
mouse 		lowest published lethal dose: 2 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		NYKZAU 55,315,1959
subcutaneous
rat 		lowest published lethal dose: 4 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		NYKZAU 55,315,1959
subcutaneous
rabbit 		lethal dose (50 percent kill): 1,500 µg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea 		JIHTAB 31,301,1949


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
guinea pig 		lowest published lethal dose: 23 mg/kg/77 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIMDAP 3,375,1909
subcutaneous
guinea pig 		lowest published lethal dose: 40 mg/kg/31 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIMDAP 3,375,1909
subcutaneous
guinea pig 		lowest published lethal dose: 15 mg/kg/28 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIMDAP 3,375,1909
subcutaneous
guinea pig 		lowest published lethal dose: 4 mg/kg/17 day- intermittent Cardiac: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIMDAP 3,375,1909


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(U)/m3;short term exposure limit 0.6 mg(U)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(U)/m3, short term exposure limit 0.6 mg(U)/m3, MAR2002
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg(U)/m3, short term exposure limit 0.6 mg(U)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 mg(U)/m3, carcinogen, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg(U)/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4655;
Number of Industries 2;
Total Number of Facilities 84;
Number of Occupations 5;
Total Number of Employees Exposed 624;
Total Number of Female Employees Exposed 465


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NJMSAG Nagoya Journal of Medical Science. (Nagoya Univ. School of Medicine, 65 Tsuruma-cho, Showa- ku, Nagoya 466, Japan) V.2- 1927-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-

RTECS Compound Description:
   Organometallic
   Reproductive Effector

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