RTECS:QU9780000 The Registry of Toxic Effects of Chemical Substances

Nitric acid, manganese (2+) salt

RTECS #: QU9780000

CAS #: 10377-66-9

UPDATE: May 2009 MW: 178.96 MF: N₂O₆•Mn

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

ACUTE TOXICITY DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Manganese (II) nitrate

Manganese (II) nitrate, anhydrous

Manganese dinitrate

Manganese nitrate

Manganese (2+) nitrate

Manganous dinitrate

Manganous nitrate

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
DNA repair Bacillus subtilis 50 mmol/L MUREAV 31,185,1975

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 56 mg/kg N/R VCVN5* -,410,1989

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m³ DTLVS* TLV/BEI,2007

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air ceiling concentration 5 mg(Mn)/m³ DTLVS* 3,149,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m³ CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m³ CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m³ CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m³ CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m³ (dust), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m³, short term exposure limit 3 mg(Mn)/m³ (fume), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Mn)/m³, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m³ (dust), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m³ (fume), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Mn)/m³, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Mn)/m³ (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg(Mn)/m³, short term exposure limit 20 mg(Mn)/m³, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 mg(Mn)/m³ (respirable dust), APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 mg(Mn)/m³, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(Mn)/m³;
short term exposure limit 3 mg(Mn)/m³, 2004
Occupational Exposure Limit - MEXICO time-weighted average 1 mg(Mn)/m³ (fume), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg(Mn)/m³, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2.5 mg(Mn)/m³, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(Mn)/m³, MAC( continuous) 5 mg(Mn)/m³, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.2 mg(Mn)/m³, (total dust);
time-weighted average 0.1 mg(Mn)/m³, (resp.dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Mn)/m³, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Mn)/m³, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m³
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m³

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81886;
Number of Industries 3;
Total Number of Facilities 41;
Number of Occupations 4;
Total Number of Employees Exposed 841
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81886;
Number of Industries 10;
Total Number of Facilities 612;
Number of Occupations 17;
Total Number of Employees Exposed 7,066;
Total Number of Female Employees Exposed 1,070

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

NIOSH PROFILE (MANGANESE and ITS COMPOUNDS), SRC, 4/82

RTECS Compound Description:
Mutagen

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SYNONYMS:
Manganese (II) nitrate Manganese (II) nitrate, anhydrous Manganese dinitrate Manganese nitrate	Manganese (2+) nitrate Manganous dinitrate Manganous nitrate

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
DNA repair	Bacillus subtilis	50 mmol/L	MUREAV 31,185,1975

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 56 mg/kg	N/R	VCVN5* -,410,1989

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 0.2 mg(Mn)/m³	DTLVS* TLV/BEI,2007

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air	ceiling concentration 5 mg(Mn)/m³	DTLVS* 3,149,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	ceiling concentration 5 mg(Mn)/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	ceiling concentration 5 mg(Mn)/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	ceiling concentration 5 mg(Mn)/m³	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	ceiling concentration 5 mg(Mn)/m³	CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA	time-weighted average 1 mg(Mn)/m³ (dust), JUL2008
Occupational Exposure Limit - AUSTRALIA	time-weighted average 1 mg(Mn)/m³, short term exposure limit 3 mg(Mn)/m³ (fume), JUL2008
Occupational Exposure Limit - BELGIUM	time-weighted average 0.2 mg(Mn)/m³, MAR2002
Occupational Exposure Limit - DENMARK	time-weighted average 0.2 mg(Mn)/m³ (dust), OCT 2002
Occupational Exposure Limit - DENMARK	time-weighted average 0.2 mg(Mn)/m³ (fume), OCT 2002
Occupational Exposure Limit - FINLAND	time-weighted average 0.5 mg(Mn)/m³, JAN1999
Occupational Exposure Limit - GERMANY	MAK 0.5 mg(Mn)/m³ (inhalable), 2005
Occupational Exposure Limit - HUNGARY	time-weighted average 5 mg(Mn)/m³, short term exposure limit 20 mg(Mn)/m³, SEP2000
Occupational Exposure Limit - JAPAN	Occupational Exposure Limit 0.3 mg(Mn)/m³ (respirable dust), APR2007
Occupational Exposure Limit - KOREA	time-weighted average 5 mg(Mn)/m³, 2006
Occupational Exposure Limit - MEXICO	time-weighted average 0.2 mg(Mn)/m³; short term exposure limit 3 mg(Mn)/m³, 2004
Occupational Exposure Limit - MEXICO	time-weighted average 1 mg(Mn)/m³ (fume), 2004
Occupational Exposure Limit - NEW ZEALAND	time-weighted average 1 mg(Mn)/m³, JAN2002
Occupational Exposure Limit - NORWAY	time-weighted average 2.5 mg(Mn)/m³, JAN1999
Occupational Exposure Limit - POLAND	MAC(time-weighted average) 0.3 mg(Mn)/m³, MAC( continuous) 5 mg(Mn)/m³, JAN1999
Occupational Exposure Limit - SWEDEN	time-weighted average 0.2 mg(Mn)/m³, (total dust); time-weighted average 0.1 mg(Mn)/m³, (resp.dust), JUN2005
Occupational Exposure Limit - SWITZERLAND	MAK- week 0.5 mg(Mn)/m³, DEC2006
Occupational Exposure Limit - UNITED KINGDOM	time-weighted average 0.5 mg(Mn)/m³, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 0.2 mg(Mn)/m³
Occupational Exposure Limit IN SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m³

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 81886; Number of Industries 3; Total Number of Facilities 41; Number of Occupations 4; Total Number of Employees Exposed 841
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 81886; Number of Industries 10; Total Number of Facilities 612; Number of Occupations 17; Total Number of Employees Exposed 7,066; Total Number of Female Employees Exposed 1,070

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
CFRGBR	Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VCVN5*	"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.