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Nickel (II) hydroxide

RTECS #: QR7040000

CAS #: 12054-48-7

UPDATE: May 2009 MW: 92.73 MF: H2NiO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Nickel dihydroxide
  1. Nickelous hydroxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 480 µg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Musculoskeletal: Tumors 		CRNGDP 4,275,1983
intramuscular
rat 		toxic dose : 60 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Tumors at site of application 		45ICAX -,59,1980


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,200 mg/m3/4 hour Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair 		RCCRC* NOTOX1074,1988
oral
rat 		lethal dose (50 percent kill): 1,515 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		ATDAEI 1,684,1992
subcutaneous
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R ZVKOA6 19,186,1974
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R RCCRC* NOTOX1074/1338,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Ni)/m3 (inhalable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 11,75,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 49,257,1990
TOXICOLOGY REVIEW
85DHAX Ni,168,1975
TOXICOLOGY REVIEW
ACLSCP 3,156,1973
TOXICOLOGY REVIEW
MUREAV 533,92,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Ni)/m3 DTLVS* 3,178,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Ni)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg(Ni)/m3, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Ni)/m3, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 1 mg(Ni)/m3, continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Ni)/m3, short term exposure limit 0.1 mg(Ni)/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg(Ni)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Ni)/m3, sen, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.25 mg(Ni)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg(Ni)/m3, Carcinogen, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg(Ni)/m3 (total dust), Carcinogen, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg(Ni)/m3, Carcinogen, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL, INORGANIC-air Carcinogen;
10 hour time-weighted average 0.015 mg(Ni)/m3 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7142;
Number of Industries 1;
Total Number of Facilities 53;
Number of Occupations 2;
Total Number of Employees Exposed 106


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a catalyst, and in nickel-cadmium batteries
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
45ICAX "Nickel Toxicology, 2nd International Conference on Nickel Toxicology, Swansea, Wales, 1980," London, Academic Press Inc., Ltd., 1980
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl., Philadelphia, PA 19103) V.1- 1971-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RCCRC* Research and Consulting Company, Technical Reports. (RCC NOTOX B.V., Hambakenwetering 7, 5231 DD 's-Hertogenbosch, Netherlands)
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I. Mendeleeva. Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.5- 1960-

Used as a catalyst, and in nickel-cadmium batteries

RTECS Compound Description:
   Tumorigen

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