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Nickel (II) acetate (1:2)

RTECS #: QR6125000

CAS #: 373-02-4

UPDATE: May 2009 MW: 176.81 MF: C4H6O4•Ni


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Acetic acid, nickel (2+) salt
  2. Nickel acetate
  1. Nickel diacetate
  2. Nickelous acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis intraperitoneal
rat 		129 µmol/kg/5 day- intermittent CRNGDP 6,1819,1985
morphological transform hamster kidney 225 mg/L IAPUDO 53,193,1984
morphological transform human fibroblast 10 µmol/L CNREA8 47,3815,1987
phage inhibition capacity Escherichia coli 40 µmol/L ENMUDM 6,59,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
hamster 		lowest published toxic dose: 10 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ADTEAS 5,51,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 95 mg/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		PAACA3 5,50,1964
intramuscular
rat 		lowest published toxic dose: 420 mg/kg/47 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		NCIUS* PH43-64-886
intramuscular
rat 		toxic dose : 225 mg/kg/46 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		NCIUS* PH43-64-886
intraperitoneal
mouse 		lowest published toxic dose: 360 mg/kg/8 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		CNREA8 36,1744,1976
intraperitoneal
rat 		lowest published toxic dose: 15,912 µg/kg (16-18 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Endocrine: Tumors 		CRNGDP 13,1351,1992
intraperitoneal
rat 		toxic dose : 15,912 µg/kg (17 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Endocrine: Tumors 		CRNGDP 13,1351,1992


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 32 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		PWPSA8 11,39,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 23 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		PWPSA8 11,39,1968
oral
mouse 		lethal dose (50 percent kill): 410 mg/kg N/R PWPSA8 11,39,1968
oral
rat 		lethal dose (50 percent kill): 350 mg/kg N/R PWPSA8 11,39,1968
subcutaneous
guinea pig 		lowest published lethal dose: 20 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		JOHYAY 8,565,1908


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 25,297 mg/kg/4 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		JANSAG 28,620,1969
oral
rat 		lowest published toxic dose: 1,581 mg/kg/6 week- continuous Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		TXAPA9 25,323,1973
oral
rat 		lowest published toxic dose: 840 mg/kg/4 week- continuous Nutritional and Gross Metabolic: Changes in: Fe

Nutritional and Gross Metabolic: Changes in: Other metals 		AJPHAP 238,53,1980


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Ni)/m3 (inhalable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMSUDL 7,264,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 49,257,1990
TOXICOLOGY REVIEW
ADTEAS 5,51,1972
TOXICOLOGY REVIEW
85DHAX Ni,168,1975
TOXICOLOGY REVIEW
ACLSCP 3,156,1973
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
MUREAV 533,92,2003
TOXICOLOGY REVIEW
MUREAV 533,183,2003
TOXICOLOGY REVIEW
MUREAV 533,227,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Ni)/m3 DTLVS* 3,178,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Ni)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg(Ni)/m3, MAR2002
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Ni)/m3, short term exposure limit 0.1 mg(Ni)/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg(Ni)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Ni)/m3, sen, JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 mg(Ni)/m3, Carcinogen, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg(Ni)/m3 (total dust), Carcinogen, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg(Ni)/m3, Carcinogen, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL, INORGANIC-air Carcinogen;
10 hour time-weighted average 0.015 mg(Ni)/m3 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81906;
Number of Industries 6;
Total Number of Facilities 128;
Number of Occupations 13;
Total Number of Employees Exposed 2,489
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81906;
Number of Industries 18;
Total Number of Facilities 481;
Number of Occupations 12;
Total Number of Employees Exposed 6,772;
Total Number of Female Employees Exposed 281


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a mordant in the textile industry, and as a hydrogenation catalyst
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl., Philadelphia, PA 19103) V.1- 1971-
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942-
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1901-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a mordant in the textile industry, and as a hydrogenation catalyst

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 17593-69-0
 Click Here for Additional Information about RTECS

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