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2 - Naphthol, 1 - (phenylazo) -

RTECS #: QL4900000

CAS #: 842-07-9

UPDATE: November 2007 MW: 248.30 MF: C16H12N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - (Phenylazo) - 2 - naphthalenol
  2. 1 - Benzeneazo - 2 - naphthol
  3. 1 - Benzoazo - 2 - naphthol
  4. 1 - Phenylazo - beta - naphthol
  5. 1 - Phenylazo - 2 - naphthol
  6. Atul Orange R
  7. Benzeneazo - beta - naphthol
  8. Benzene - 1 - azo - 2 - naphthol
  9. Brasilazina Oil Orange
  10. Brilliant Oil Orange R
  11. C.I. 12055
  12. C.I. Solvent Yellow 14
  13. Calco Oil Orange 7078
  14. Calco Oil Orange 7078 - Y
  15. Calco Oil Orange Z - 7078
  16. Calcogas M
  17. Calcogas Orange NC
  18. Campbelline Oil Orange
  19. Carminaph
  20. Ceres Orange R
  21. Cerotinorange G
  22. Dispersol Yellow PP
  23. Dunkelgelb
  24. Enial Orange I
  25. Fast Oil Orange I
  26. Fast Orange
  27. Fat Orange 4A
  28. Fat Orange G
  29. Fat Orange I
  30. Fat Orange R
  31. Fat Orange RS
  32. Grasal Orange
  33. Grasan Orange R
  34. Hidaco Oil Orange
  35. Lacquer Orange VG
  36. Morton Orange Y
  37. NCI - C53929
  38. Oil Orange
  39. Oil Orange 31
  40. Oil Orange 2311
  41. Oil Orange 2B
  42. Oil Orange E
  43. Oil Orange EP
  1. Oil Orange PEL
  2. Oil Orange PS
  3. Oil Orange R
  4. Oil Orange R - 14
  5. Oil Orange 7078 - V
  6. Oil Orange Z - 7078
  7. Oil Soluble Orange
  8. Oleal Orange R
  9. Orange a l'huile
  10. Orange 2 insoluble
  11. Orange PEL
  12. Orange 3RA soluble in grease
  13. Orange Resenole No. 3
  14. Orange R Fat Soluble
  15. Orange soluble a l'huile
  16. Organol Orange
  17. Orient Oil Orange PS
  18. Petrol Orange Y
  19. Plastoresin Orange F4A
  20. Pyronalorange
  21. Resinol Orange R
  22. Resoform Orange G
  23. Sansel Orange G
  24. Scharlach B
  25. Silotras Orange TR
  26. Solvent Yellow 14
  27. Somalia Orange I
  28. Spirit Orange
  29. Spirit Yellow I
  30. Stearix Orange
  31. Sudan 1
  32. Sudan I
  33. Sudan Orange R
  34. Sudan Orange RA
  35. Sudan Orange RA New
  36. Tertrogras Orange SV
  37. Toyo Oil Orange
  38. Waxakol Orange GL
  39. Waxoline Yellow I
  40. Waxoline Yellow IM
  41. Waxoline Yellow IP
  42. Waxoline Yellow IS
  43. Zlut rozpoustedlova 14 (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human other cell types 25 µmol/L/1 hour MUREAV 627,164,2007
DNA damage oral
mouse 		1 gm/kg MUREAV 465,11,2000
unscheduled DNA synthesis oral
rat 		500 mg/kg CBTOE2 3,193,1987
mutation in microorganisms mouse lymphocyte 4 mg/L (+enzymatic activation step) SCIEAS 236,933,1987
mutation in microorganisms Salmonella typhimurium 300 ng/plate (-enzymatic activation step) SCIEAS 236,933,1987
mutation in microorganisms Salmonella typhimurium 5 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004
micronucleus test human other cell types 50 µmol/L/24 hour MUREAV 627,164,2007
micronucleus test oral
rat 		250 mg/kg CRNGDP 12,1403,1991
mutation in mammalian somatic cells mouse lymphocyte 37 mg/L MUREAV 189,223,1987
sister chromatid exchange hamster ovary 8,200 µg/L SCIEAS 236,933,1987
specific locus test mouse lymphocyte 8 mg/L EMMUEG 17,196,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 80 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		BJCAAI 22,825,1968
implant
mouse 		toxic dose : 75 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		CALEDQ 6,21,1979
implant
mouse 		toxic dose : 96 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		GMCRDC 17,383,1975
oral
mouse 		lowest published toxic dose: 21,630 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-226,1982
oral
mouse 		lowest published toxic dose: 43,260 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease 		NTIS** PB83-126474
oral
rat 		lowest published toxic dose: 10,815 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-226,1982
oral
rat 		lowest published toxic dose: 21,630 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB83-126474
oral
rat 		lowest published toxic dose: 18,025 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB83-126474
subcutaneous
mouse 		lowest published toxic dose: 6,000 mg/kg/57 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application 		GMJOAZ 30,364,1949


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 87,360 mg/kg/13 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-226,1982
oral
rat 		lowest published toxic dose: 4,200 mg/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-226,1982
oral
rat 		lowest published toxic dose: 9,012.5 mg/kg/103 week- continuous Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Active as anti-cancer agent 		NTIS** PB83-126474


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 8,225,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 8,225,1975
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
AEHLAU 23,6,1971
TOXICOLOGY REVIEW
ADCSAJ 13,271,1970
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2105;
Number of Industries 34;
Total Number of Facilities 1,715;
Number of Occupations 32;
Total Number of Employees Exposed 44,358;
Total Number of Female Employees Exposed 6,755


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for coloring hydrocarbon solvents, oils, fats, waxes, shoe and floor polishes, petrol
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:rat
NCI Carcinogenesis Studies (feed);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GMJOAZ Glasgow Medical Journal. (Glasgow, Scotland) 1828-1955. For publisher information, see SMDJAK.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-

Used for coloring hydrocarbon solvents, oils, fats, waxes, shoe and floor polishes, petrol

RTECS Compound Description:
   Tumorigen
   Mutagen

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