The Registry of Toxic Effects of Chemical Substances

1 - Naphthol

RTECS #: QL2800000

CAS #: 90-15-3

UPDATE: February 2006 MW: 144.18 MF: C10H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxynaphthalene
  2. 1 - Naphthalenol
  3. Basf Ursol ERN
  4. C.I. 76605
  5. C.I. Oxidation Base 33
  6. Durafur developer D
  7. Fouramine ERN
  8. Fourrine 99
  1. Fourrine ERN
  2. Furro ER
  3. Nako TRB
  4. Tertral ERN
  5. Ursol ERN
  6. Zoba ERN
  7. alpha - Hydroxynaphthalene
  8. alpha - Naphthol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg severe UCDS** 11/10/1964
skin
rabbit 		550 mg open irritation test moderate UCDS** 11/10/1964


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 5 gm/L MUREAV 42,19,1977
DNA repair Escherichia coli 2 mg/disc MUREAV 97,1,1982
mutation in microorganisms Salmonella typhimurium 500 µg/plate (-enzymatic activation step) BJCAAI 37,873,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 90 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 250 mg/kg N/R TSCAT* FYI-OTS-0885-0443
oral
cat 		lethal dose (50 percent kill): 134 mg/kg N/R GISAAA 30(9),22,1965
oral
cat 		lethal dose (50 percent kill): 130 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
guinea pig 		lethal dose (50 percent kill): 2 gm/kg N/R GISAAA 30(9),22,1965
oral
guinea pig 		lethal dose (50 percent kill): 2,000 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
mouse 		lethal dose (50 percent kill): 275 mg/kg N/R GISAAA 30(9),22,1965
oral
mouse 		lethal dose (50 percent kill): 275 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
rat 		lethal dose (50 percent kill): 1,870 mg/kg N/R TSCAT* FYI-OTS-0885-0443
oral
rat 		lethal dose (50 percent kill): 2,000 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
rabbit 		lethal dose (50 percent kill): 9 gm/kg N/R GISAAA 30(9),22,1965
oral
rabbit 		lethal dose (50 percent kill): 9,000 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
rabbit 		lowest published toxic dose: 1,000 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity) 		VCVGK* -,220,1994
skin
rabbit 		lethal dose (50 percent kill): 880 mg/kg N/R AIHAAP 23,95,1962
skin
rabbit 		lethal dose (50 percent kill): 880 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
unreported route
rabbit 		lowest published lethal dose: 9,100 mg/kg N/R YKYUA6 32,605,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
human 		lowest published toxic dose: 42.8 mg/kg/3 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Proteinuria

Endocrine: Changes in spleen weight 		VCVGK* -,221,1994
oral
mouse 		lowest published toxic dose: 270 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,220,1994
oral
rat 		lowest published toxic dose: 2 gm/kg/2 week- intermittent Kidney, Ureter, and Bladder: Urine volume increased

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0533716
oral
rat 		lowest published toxic dose: 25,200 mg/kg/105 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,221,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 47,75,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81692;
Number of Industries 20;
Total Number of Facilities 1,281;
Number of Occupations 28;
Total Number of Employees Exposed 12,938
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81692;
Number of Industries 7;
Total Number of Facilities 5,497;
Number of Occupations 24;
Total Number of Employees Exposed 57,255;
Total Number of Female Employees Exposed 43,248


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to manufacture dyes, intermediates and synthetic perfumes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used to manufacture dyes, intermediates and synthetic perfumes

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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