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2 - Naphthoic acid, 4,4' - methylenebis (3 - hydroxy - , compd. with (E) - 1,4,5,6 - tetrahydro - 1 - methyl - 2 - (2 - (2 - thienyl) vinyl) pyrimidine (1:1)

RTECS #: QL2287000

CAS #: 22204-24-6

UPDATE: February 2007 MW: 594.72 MF: C23H16O6•C11H14N2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. Antiminth
  2. Combantrin
  3. Embovin
  1. Pyrantel embonate
  2. Pyrantel pamoate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Saccharomyes cerevisiae 20 mmol/L (-enzymatic activation step) MUREAV 187,79,1987
gene conversion and mitotic recombination Saccharomyes cerevisiae 5 mmol/L MUREAV 187,79,1987
sperm morphology intraperitoneal
mouse 		14.4 mg/kg/5 day MUREAV 497,131,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 60 mg/kg (1-6 day pregnant) Reproductive: Maternal effects: Parturition VMJGEA 41,23,1993
oral
mouse 		lowest published toxic dose: 180 mg/kg (1-6 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) VMJGEA 41,23,1993
oral
mouse 		lowest published toxic dose: 60 mg/kg (7-12 day pregnant) Reproductive: Maternal effects: Parturition VMJGEA 41,23,1993
oral
mouse 		lowest published toxic dose: 140 mg/kg (7-20 day pregnant) Reproductive: Effects on newborn: Stillbirth VMJGEA 41,23,1993
oral
rat 		lowest published toxic dose: 1,800 mg/kg (9-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) OYYAA2 5,41,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 620 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation 		OYYAA2 5,305,1971
intraperitoneal
rat 		lethal dose (50 percent kill): 535 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation 		OYYAA2 5,305,1971
oral
mouse 		lethal dose : >24 gm/kg Behavioral: Somnolence (general depressed activity) OYYAA2 5,305,1971
oral
rat 		lethal dose : >24 gm/kg Behavioral: Somnolence (general depressed activity) OYYAA2 5,305,1971
subcutaneous
mouse 		lowest published lethal dose: 4 gm/kg N/R OYYAA2 5,305,1971
subcutaneous
rat 		lowest published lethal dose: 6,600 mg/kg N/R OYYAA2 5,305,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
human 		lowest published toxic dose: 30 mg/kg/3 day- intermittent Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting 		AJTHAB 22,45,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
APHRER 38,383,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3221;
Number of Industries 2;
Total Number of Facilities 748;
Number of Occupations 7;
Total Number of Employees Exposed 7,070;
Total Number of Female Employees Exposed 3,365


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AJTHAB American Journal of Tropical Medicine and Hygiene. (Allen Press, 1041 New Hampshire St., Lawrence, KS 66044) V.1- 1952-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
VMJGEA Veterinary Medical Journal Giza. (Cairo University, Faculty of Veterinary Medicine, Giza, Egypt) V.37- 1989-

Used as an ancylostomiasis agent

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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