RTECS:QK2260000 The Registry of Toxic Effects of Chemical Substances

2 - Naphthalenesulfonic acid, 6 - hydroxy - 5 - ( (6 - methoxy - 4 - sulfo - m - tolyl) azo) - , disodium salt

RTECS #: QK2260000

CAS #: 25956-17-6

UPDATE: February 2003 MW: 498.46 MF: C₁₈H₁₆N₂O₈S₂•2Na

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Allura Red

Allura Red AC

C. I. 16035

C.I. Food Red 17

FD and C Red No. 40

FD&C Red No. 40

Red No. 40

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
DNA damage oral
mouse 10 mg/kg MUREAV 519,103,2002

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 198 gm/kg (4 week male/4 week prior to copulation-21 day after birth) Reproductive: Effects on newborn: Behavioral TXCYAC 92,169,1994
oral
rat lowest published toxic dose: 38,500 mg/kg (14 day male/14 day prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) TXCYAC 28,207,1983
oral
rat lowest published toxic dose: 83,500 mg/kg (2 week male/2 week prior to copulation-2 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXCYAC 28,207,1983
oral
rat lowest published toxic dose: 19,725 mg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TIHEEC 5,937,1989

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
dog lethal dose (50 percent kill): >5 gm/kg N/R FCTOD7 27,701,1989
oral
rat lethal dose (50 percent kill): >10 gm/kg N/R FCTOD7 27,701,1989
skin
rabbit lethal dose (50 percent kill): >10 gm/kg N/R FCTOD7 27,701,1989

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 3,053 gm/kg/2.3 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 27,701,1989

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0501;
Number of Industries 4;
Total Number of Facilities 1,225;
Number of Occupations 16;
Total Number of Employees Exposed 6,022
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0501;
Number of Industries 2;
Total Number of Facilities 65;
Number of Occupations 2;
Total Number of Employees Exposed 118
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3955;
Number of Industries 23;
Total Number of Facilities 3,941;
Number of Occupations 44;
Total Number of Employees Exposed 88,598;
Total Number of Female Employees Exposed 50,571

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a color additive

RTECS Compound Description:
Mutagen
Reproductive Effector

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SYNONYMS:
Allura Red Allura Red AC C. I. 16035 C.I. Food Red 17	FD and C Red No. 40 FD&C Red No. 40 Red No. 40

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
DNA damage	oral mouse	10 mg/kg	MUREAV 519,103,2002

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral mouse	lowest published toxic dose: 198 gm/kg (4 week male/4 week prior to copulation-21 day after birth)	Reproductive: Effects on newborn: Behavioral	TXCYAC 92,169,1994
oral rat	lowest published toxic dose: 38,500 mg/kg (14 day male/14 day prior to copulation)	Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)	TXCYAC 28,207,1983
oral rat	lowest published toxic dose: 83,500 mg/kg (2 week male/2 week prior to copulation-2 week after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TXCYAC 28,207,1983
oral rat	lowest published toxic dose: 19,725 mg/kg (1-21 day pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TIHEEC 5,937,1989

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral dog	lethal dose (50 percent kill): >5 gm/kg	N/R	FCTOD7 27,701,1989
oral rat	lethal dose (50 percent kill): >10 gm/kg	N/R	FCTOD7 27,701,1989
skin rabbit	lethal dose (50 percent kill): >10 gm/kg	N/R	FCTOD7 27,701,1989

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 3,053 gm/kg/2.3 year- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 27,701,1989

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: T0501; Number of Industries 4; Total Number of Facilities 1,225; Number of Occupations 16; Total Number of Employees Exposed 6,022
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: T0501; Number of Industries 2; Total Number of Facilities 65; Number of Occupations 2; Total Number of Employees Exposed 118
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X3955; Number of Industries 23; Total Number of Facilities 3,941; Number of Occupations 44; Total Number of Employees Exposed 88,598; Total Number of Female Employees Exposed 50,571

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
FCTOD7	Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TIHEEC	Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-