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2,7 - Naphthalenedisulfonic acid, 3 - hydroxy - 4 - ( (2,4,5 - trimethylphenyl) azo) - , disodium salt

RTECS #: QJ6650000

CAS #: 3564-09-8

UPDATE: November 2007 MW: 494.47 MF: C19H16N2O7S2•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 3 - Hydroxy - 4 - ( (2,4,5 - trimethylphenyl) azo) - 2,7 - naphthalenedisulphonic acid, disodium salt
  2. A.F. Red No. 1
  3. C.I. 16155
  4. C.I. Food Red 6
  5. C.I. Food Red 6, disodium salt
  6. Cerven kumidinova (Czech)
  7. Cerven potravinarska 6 (Czech)
  8. Disodium 3 - hydroxy - 4 - ( (2,4,5 - trimethylphenyl) azo) - 2,7 - naphthalenedisulfonate
  9. Disodium 3 - hydroxy - 4 - ( (2,4,5 - trimethylphenyl) azo) - 2,7 - naphthalenedisulphonate
  10. Dolkwal Ponceau 3R
  11. Ext D and C Red No. 15
  1. FD and C Red No. 1
  2. Maple Ponceau 3R
  3. Ponceau 3R
  4. Ponceau RN
  5. Ponceau 3R Lake
  6. Ponceau 3RN
  7. Ponceau 3R sodium salt
  8. Sodium cumeneazo - beta - naphthol disulfonate
  9. Sodium cumeneazo - beta - naphthol disulphonate
  10. Usacert Red No. 1


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage oral
mouse 		2 gm/kg MUREAV 465,11,2000
mutation in microorganisms mouse lymphocyte 1,701 mg/L (+enzymatic activation step) MUREAV 189,223,1987
mutation in microorganisms Salmonella typhimurium 660 nmol/plate (-enzymatic activation step) INFIBR 23,686,1979
other mutation test systems Escherichia coli 300 µmol/L SKEZAP 12,298,1971
specific locus test mouse liver 3,440 µmol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 80 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		BJCAAI 17,127,1963
oral
mouse 		lowest published toxic dose: 1,640 gm/kg/65 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		TXAPA9 3,509,1961
oral
mouse 		toxic dose : 1,140 gm/kg/68 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		TXAPA9 5,105,1963
oral
rat 		lowest published toxic dose: 730 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		TXAPA9 5,105,1963
oral
rat 		toxic dose : 200 gm/kg/24 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		TXAPA9 5,105,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 8,199,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 8,199,1975
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
ARVPAX 14,127,1974
TOXICOLOGY REVIEW
AEHLAU 23,6,1971
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83806;
Number of Industries 2;
Total Number of Facilities 131;
Number of Occupations 3;
Total Number of Employees Exposed 827
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83806;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 36;
Total Number of Female Employees Exposed 16


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay


REFERENCES:

CODEN
REFERENCE
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INFIBR Infection and Immunity. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1970-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used for dyeing wool, and as a food colorant

RTECS Compound Description:
   Tumorigen
   Mutagen

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