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2,7 - Naphthalenedisulfonic acid, 3 - hydroxy - 4 - ( (4 - sulfo - 1 - naphthalenyl) azo) - , trisodium salt

RTECS #: QJ6530000

CAS #: 2611-82-7

UPDATE: May 2009 MW: 607.51 MF: C20H14N2O10S3•3Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - (4 - Sulpho - 1 - naphthylazo) - 2 - naphthol - 6,8 - disulphonic acid, trisodium salt
  2. 1578 Red
  3. Acid Brilliant Scarlet 3R
  4. Acid Ponceau 4R
  5. Acid Red 18
  6. Acid Scarlet 3R
  7. Acid Scarlet 4R
  8. Acid Scarlet 3RZ
  9. Acidal Bright Ponceau 3R
  10. Acilan Scarlet V3R
  11. Aizen Brilliant Scarlet 3RH
  12. Atul Acid Scarlet 3R
  13. Atul Scarlet F
  14. Brilliant Ponceau 3R
  15. Brilliant Ponceau 4R
  16. Brilliant Ponceau 5R
  17. Brilliant Ponceau 4RC
  18. Brilliant Ponceau 4RC Specially Pure
  19. Brilliant Ponceau 3RF
  20. Brilliant Scarlet
  21. Brilliant Scarlet 3R
  22. Brilliant Scarlet 4R
  23. Bucacid Brilliant Scarlet 3R
  24. C.I. 16255
  25. C.I. 185
  26. C.I. Acid Red 18
  27. C.I. Acid Red 18, trisodium salt
  28. C.I. Food Red 7
  29. Calcocid Brilliant Scarlet 3RN
  30. Certicol Ponceau 4RS
  31. Cerven kosenilova A (Czech)
  32. Cerven kysela 18 (Czech)
  33. Cerven potravinarska 7 (Czech)
  34. Cilefa Ponceau 4R
  35. Coccin Red
  36. Coccine
  37. Coccine nouvelle (French)
  38. Cochenillerot A (German)
  39. Cochineal Red A
  40. Cochineal Red A Specially Pure
  41. Cochineal Red 4R
  42. Colacid Ponceau 4R
  43. Crimson SX
  44. Curol Bright Red 4R
  45. Daishiki Brilliant Scarlet 3R
  46. E 124
  47. Edicol Supra Ponceau 4R
  1. Eurocert Cochineal Red A
  2. Fenazo Scarlet 3R
  3. Food Red 6
  4. Food Red 7
  5. Food Red No. 102
  6. HD Ponceau 4R
  7. HD Ponceau 4R Supra
  8. Hexacol Ponceau 4R
  9. Hidacid Fast Scarlet 3R
  10. Hispacid Brilliant Scarlet 3RF
  11. Java Scarlet 3R
  12. Kayaku Acid Brilliant Scarlet 3R
  13. Kayaku Food Colour Red No. 102
  14. Kiton Scarlet 4R
  15. Kochineal Red A for food
  16. L - Rot 4 (German)
  17. Naphthalene Scarlet 4R
  18. Naphthalene Scarlet 4RS
  19. Naphthalene Ink Scarlet 4R
  20. Neklacid Red 3R
  21. Neklacid Red 4R
  22. Neucoccin (German)
  23. New Coccine Extra Conc. A Export
  24. New Coccine Extra Pure A
  25. New coccin
  26. New coccine
  27. Ponceau 4R
  28. Ponceau 4R Aluminum Lake
  29. Ponceau 4RE
  30. Ponceau 4RE.FQ
  31. Ponceau 4RF
  32. Ponceau 4RT
  33. Pontacyl Scarlet RR
  34. Purple Red
  35. Purple SX
  36. Rakuto Brilliant Scarlet 3R
  37. Rouge de cochenille A (French)
  38. SX purple
  39. San - ei Brilliant Scarlet 3R
  40. Schultz Nr. 213 (German)
  41. Strawberry Red A Geigy
  42. Sugai Brilliant Scarlet 3R
  43. Symulon Acid Brilliant Scarlet 3R
  44. Takaoka Brilliant Scarlet 3R
  45. Victoria Scarlet 3R
  46. Victoria Scarlet Red
  47. Victoria Scharlach 4 R Extra (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 1 gm/L FCTOD7 22,623,1984
DNA damage oral
mouse 		10 mg/kg MUREAV 519,103,2002
sperm morphology mammal (species unspecified) other cell types 8.3 µg/L/76 day- intermittent TOVEFN (2),37,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 8.3 mg/m3 (1-7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		TOVEFN (2),37,1996
inhalation
rat 		lowest published toxic concentration: 1.8 mg/m3 (76 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Sex ratio 		TOVEFN (1),38,1998
oral
mouse 		lowest published toxic dose: 133 gm/kg (28 day male/28 day prior to copulation-28 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		FCTOD7 44,1651,2006
oral
mouse 		lowest published toxic dose: 65 gm/kg (28 day male/28 day prior to copulation-28 day after birth) Reproductive: Effects on newborn: Behavioral FCTOD7 44,1651,2006
oral
mouse 		lowest published toxic dose: 73.54 gm/kg (multigeneration) Reproductive: Effects on newborn: Behavioral FCTOD7 44,1651,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 428 gm/kg/64 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		VPITAR 29,61,1970


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 70 mg/m3 Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes 		TOVEFN (2),37,1996
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		FCTXAV 5,187,1967
intraperitoneal
rat 		lethal dose (50 percent kill): 600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		FCTXAV 5,187,1967
intraperitoneal
rat 		lethal dose (50 percent kill): 1,120 mg/kg Behavioral: Excitement TOVEFN (2),37,1996
intravenous
rat 		lethal dose (50 percent kill): 1 gm/kg N/R SCPHA4 47,39,1979
oral
mouse 		lowest published lethal dose: 8 gm/kg N/R SCPHA4 47,39,1979
oral
mouse 		lethal dose (50 percent kill): >10,000 mg/kg Behavioral: Excitement TOVEFN (2),37,1996
oral
rat 		lethal dose (50 percent kill): >8 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		FCTXAV 5,187,1967
oral
rat 		lethal dose (50 percent kill): >10,000 mg/kg Behavioral: Excitement TOVEFN (2),37,1996
unreported route
rat 		lethal dose (50 percent kill): 2 gm/kg N/R NAIZAM 30,179,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 48 mg/m3/61 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOVEFN (2),37,1996
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 48 mg/m3/91 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia TOVEFN (2),37,1996
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 48 mg/m3/14 day- intermittent Blood: Other changes

Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count 		TOVEFN (2),37,1996
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 8.3 mg/m3/122 day- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count 		TOVEFN (2),37,1996
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 8.3 mg/m3/122 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Increase in humoral response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOVEFN (2),37,1996
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 8.3 mg/m3/61 day- intermittent Liver: Liver function tests impaired

Blood: Hemorrhage

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		TOVEFN (2),37,1996
inhalation
rat 		lowest published toxic concentration: 48 mg/m3/17 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Liver function tests impaired

Blood: Other changes 		TOVEFN (2),34,1996
oral
rat 		lowest published toxic dose: 143 gm/kg/90 day- continuous Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		FCTXAV 5,187,1967
oral
rat 		lowest published toxic dose: 30 gm/kg/30 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition 		TOVEFN (2),34,1996
oral
rat 		lowest published toxic dose: 30,000 mg/kg/30 day- intermittent Vascular: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition 		TOVEFN (2),37,1996
oral
rat 		lowest published toxic dose: 30,000 mg/kg/30 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		TOVEFN (2),37,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HUTOX* -,259,1996
TOXICOLOGY REVIEW
HUTOX* -,259,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4494;
Number of Industries 1;
Total Number of Facilities 46;
Number of Occupations 1;
Total Number of Employees Exposed 138
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4494;
Number of Industries 5;
Total Number of Facilities 1,035;
Number of Occupations 9;
Total Number of Employees Exposed 8,379;
Total Number of Female Employees Exposed 2,006


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
HUTOX*
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950-
SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952-

Used as a dye, pigment, printing ink, food and feed additive, flavor, packaging material

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 39470-82-1
 Click Here for Additional Information about RTECS

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