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1,3 - Naphthalenedisulfonic acid, 6,6' - ( (3,3' - dimethyl - 4,4' - biphenylylene) bis (azo) ) bis (4 - amino - 5 - hydroxy - , tetrasodium salt

RTECS #: QJ6440000

CAS #: 314-13-6

UPDATE: May 2008 MW: 960.84 MF: C34H24N6O14S4•4Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 4,4' - Bis (1 - amino - 8 - hydroxy - 2,4 - disulfo - 7 - naphthylazo) - 3,3' - bitolyl, tetrasodium salt
  2. 4,4' - Bis (7 - (1 - amino - 8 - hydroxy - 2,4 - disulfo) naphthylazo) - 3,3' - bitolyl, tetrasodium salt
  3. 4,4' - Bis (1 - amino - 8 - hydroxy - 2,4 - disulpho - 7 - naphthylazo) - 3,3' - bitolyl, tetrasodium salt
  4. 4,4' - Bis (7 - (1 - amino - 8 - hydroxy - 2,4 - disulpho) naphthylazo) - 3,3' - bitolyl, tetrasodium salt
  5. Azovan Blue
  6. Blekit evansa (Polish)
  7. C.I. 23860
  8. C.I. Direct Blue 53
  9. C.I. Direct Blue 53, tetrasodium salt
  10. Diamine Sky Blue FF
  11. Diazobleu
  12. Diazol Pure Blue BF
  1. Direct Blue 53
  2. Dye Evans Blue
  3. Evablin
  4. Evans Blue
  5. Evans Blue Dye
  6. Evans blue, sodium salt
  7. Geigy Blue 536, med
  8. Geigy - blau 536
  9. Modr Evansova (Czech)
  10. Modr Prima 53 (Czech)
  11. T 1824


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct skin
mouse 		192 µmol/kg CRNGDP 5,231,1984
unscheduled DNA synthesis hamster liver 10 µmol/L MUREAV 136,255,1984
unscheduled DNA synthesis rat liver 100 µmol/L MUREAV 136,255,1984
unscheduled DNA synthesis oral
rat 		200 mg/kg ENMUDM 7,101,1985
mutation in microorganisms Salmonella typhimurium 33 µg/plate (-enzymatic activation step) CRNGDP 3,21,1982
mutation in mammalian somatic cells mouse lymphocyte 1,001 mg/L MUREAV 189,223,1987
phage inhibition capacity Escherichia coli 100 mmol/L MDMIAZ 31,11,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 70 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear 		PSEBAA 127,215,1968
intraperitoneal
rat 		lowest published toxic dose: 70 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) PSEBAA 127,215,1968
intraperitoneal
rat 		lowest published toxic dose: 140 mg/kg (8 day pregnant) Reproductive: Other effects to embryo or fetus TJADAB 2,85,1969
subcutaneous
rat 		lowest published toxic dose: 150 mg/kg (7-9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system ANREAK 118,369,1954


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 850 mg/kg/34 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Leukemia 		APHGBP 33,1,1953


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 340 mg/kg N/R BBRCA9 136,64,1986
intravenous
cat 		lowest published lethal dose: 1 mL/kg Gastrointestinal: Hypermotility, diarrhea

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		ARSUAX 48,17,1944
intravenous
dog 		lowest published lethal dose: 3 mL/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Lung, Thorax, or Respiration: Acute pulmonary edema 		ARSUAX 48,17,1944
intravenous
rat 		lowest published lethal dose: 5 mL/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema 		ARSUAX 48,17,1944
intravenous
rabbit 		lowest published lethal dose: 1 mL/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema 		ARSUAX 48,17,1944


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 620 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BBRCA9 136,64,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 8,151,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 8,151,1975
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
ADTEAS 1,131,1966
TOXICOLOGY REVIEW
MUREAV 588,88,2005
TOXICOLOGY REVIEW
MUREAV 612,58,2006
TOXICOLOGY REVIEW
TOPADD 33,517,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0844;
Number of Industries 3;
Total Number of Facilities 162;
Number of Occupations 6;
Total Number of Employees Exposed 5,350;
Total Number of Female Employees Exposed 2,829


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for dyeing textiles, leather and paper
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
APHGBP Acta Pathologica (Belgrade). (Belgrade Univerzitet, Institute de Pathologie, Belgrade, Yugoslavia) V.2/3- 1938-
ARSUAX Archives of Surgery (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-61, 1920-50; V.81- 1960-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-

Used for dyeing textiles, leather and paper

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

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