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Morphinan - 3,6 - alpha,14 - triol, 17 - (cyclobutylmethyl) - 4,5 - alpha - epoxy - , hydrochloride

RTECS #: QD3181000

CAS #: 23277-43-2

UPDATE: May 2008 MW: 393.95 MF: C21H27NO4•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. REFERENCES:

SYNONYMS:

  1. 17 - Cyclobutylmethyl - 4,5 - alpha - epoxymorphinan - 3,6 - alpha,14 - triol hydrochloride
  2. En 2234A
  3. Morphinan - 3,6,14 - triol, 17 - (cyclobutylmethyl) - 4,5 - epoxy - , hydrochloride, (5 - alpha,6 - alpha) -
  4. N - Cyclobutylmethyl - 14 - hydroxydihydronormorphine hydrochloride
  1. Nalbufina clorhidrato (Spanish)
  2. Nalbuphine hydrochloride
  3. Nubain


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
pigeon 		lowest published toxic dose: 1.77 mg/kg Behavioral: Alteration of operant conditioning PSCHDL 160,132,2002
intraperitoneal
mouse 		lowest published toxic dose: 4.2 mg/kg Behavioral: Alteration of operant conditioning JPETAB 318,1300,2006
intraperitoneal
mouse 		lowest published toxic dose: 3.4 mg/kg Behavioral: Analgesia JPETAB 318,1300,2006
intraperitoneal
rat 		lowest published toxic dose: 0.3 mg/kg Behavioral: Alteration of operant conditioning PSCHDL 167,265,2003
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg Behavioral: Change in motor activity (specific assay) PSCHDL 167,265,2003
intraperitoneal
rat 		lowest published toxic dose: 1.43 mg/kg Behavioral: Analgesia PSCHDL 168,426,2003
intravenous
dog 		lethal dose (50 percent kill): 140 mg/kg N/R MDACAP 16,51,1980
intravenous
woman 		lowest published toxic dose: 800 µg/kg Lung, Thorax, or Respiration: Acute pulmonary edema CHETBF 90,773,1986
oral
dog 		lethal dose (50 percent kill): 1,100 mg/kg N/R MDACAP 16,51,1980
parenteral
rat 		lowest published toxic dose: 1.4 µg/kg Behavioral: Analgesia PSCHDL 191,273,2007
subcutaneous
dog 		lethal dose (50 percent kill): 200 mg/kg N/R MDACAP 16,51,1980
subcutaneous
monkey 		lowest published toxic dose: 32 mg/kg Behavioral: Analgesia

Behavioral: Alteration of operant conditioning 		JPETAB 294,168,2000
subcutaneous
monkey 		lowest published toxic dose: 1 mg/kg Behavioral: Alteration of operant conditioning JPETAB 294,168,2000
subcutaneous
rat 		lowest published toxic dose: 0.38 mg/kg Behavioral: Change in psychophysiological tests JPETAB 302,101,2002
subcutaneous
rat 		lowest published toxic dose: 17 mg/kg Behavioral: Alteration of operant conditioning

Behavioral: Change in psychophysiological tests 		JPETAB 302,101,2002
subcutaneous
rat 		lowest published toxic dose: 3.05 mg/kg Behavioral: Analgesia PSCHDL 191,273,2007


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5314;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 314


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
CHETBF Chest. (American College of Chest Physicians, 911 Busse Hwy, Park Ridge, IL 60068) V.57- 1970-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-

Used as an analgesic agent

RTECS Compound Description:
   Drug
   Human Data

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