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Morphinan - 6 - one, 4,5 - alpha - epoxy - 3 - hydroxy - 17 - methyl - , hydrochloride, (5' - alpha) -

RTECS #: QD2625000

CAS #: 71-68-1

UPDATE: November 2007 MW: 321.83 MF: C17H19NO3•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. 4,5 - alpha - Epoxy - 3 - hydroxy - 17 - methylmorphinan - 6 - one hydrochloride
  2. Dihydromorphinone hydrochloride
  3. Dilaudid
  4. Dilaudid hydrochloride
  1. Hydromorphone hydrochloride
  2. Hymorphan
  3. Laudicon


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
hamster 		lowest published toxic dose: 21,500 µg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system AJOGAH 123,705,1975
subcutaneous
hamster 		lowest published toxic dose: 44 mg/kg (8 day pregnant) Reproductive: Other developmental abnormalities AJOGAH 123,705,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
human 		lowest published toxic dose: 0.4 mg/kg Behavioral: Muscle weakness PSCHDL 157,151,2001
intramuscular
human 		lowest published toxic dose: 0.8 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Euphoria

Lung, Thorax, or Respiration: Respiratory depression 		PSCHDL 157,151,2001
intravenous
cat 		lowest published lethal dose: 3 mg/kg Behavioral: Analgesia

Lung, Thorax, or Respiration: Other changes 		AEPPAE 194,296,1940
intravenous
mouse 		lethal dose (50 percent kill): 55 mg/kg N/R TXAPA9 6,334,1964
intravenous
rabbit 		lowest published lethal dose: 2,500 µg/kg Behavioral: Analgesia

Lung, Thorax, or Respiration: Other changes 		AEPPAE 194,296,1940
subcutaneous
mouse 		lethal dose (50 percent kill): 120 mg/kg N/R ARZNAD 3,238,1953
subcutaneous
rat 		lethal dose (50 percent kill): 51 mg/kg N/R ARZNAD 3,238,1953


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraspinal
dog 		lowest published toxic dose: 8.4 mg/kg/28 day- continuous Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Change in motor activity (specific assay)

Behavioral: Stiffness 		TOXID9 72,386,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AJEMEN 20,151,2002
TOXICOLOGY REVIEW
ENTOX* -,552,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1125;
Number of Industries 1;
Total Number of Facilities 56;
Number of Occupations 2;
Total Number of Employees Exposed 725
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1125;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 2;
Total Number of Employees Exposed 549;
Total Number of Female Employees Exposed 257


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an analgesic

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

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