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Morphinan - 6 - one, 4,5 - alpha - epoxy - 3 - hydroxy - 17 - methyl -

RTECS #: QD2500000

CAS #: 466-99-9

UPDATE: May 2009 MW: 285.37 MF: C17H19NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. ( - ) - Hydromorphone
  2. DiMo
  3. Dihydromorfinon (Czech)
  1. Dihydromorphinone
  2. Hydromorphone
  3. Morphinone, dihydro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
human 		lowest published toxic dose: 0.14 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Euphoria

Cardiac: Change in rate 		PSCHDL 154,230,2001
intravenous
mouse 		lethal dose (50 percent kill): 104 mg/kg Peripheral Nerve and Sensation: Local anesthetic

Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression 		YKKZAJ 84,268,1964
oral
human 		lowest published lethal dose: 1,428 µg/kg N/R 34ZIAG -,223,1969
subcutaneous
mouse 		lethal dose (50 percent kill): 84 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Stiffness

Behavioral: Muscle contraction or spasticity 		JPETAB 52,468,1934
subcutaneous
rat 		lowest published toxic dose: 0.27 mg/kg Behavioral: Analgesia

Behavioral: Change in psychophysiological tests 		JPETAB 316,1195,2006


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
man 		lowest published toxic dose: 0.143 mg/kg/2 day- intermittent Behavioral: Muscle contraction or spasticity APHRER 40,2068,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
APHRER 38,1015,2004
TOXICOLOGY REVIEW
ENTOX* -,552,2005
TOXICOLOGY REVIEW
AJEMEN 22,404,2004
TOXICOLOGY REVIEW
APHRER 40,1327,2006
TOXICOLOGY REVIEW
HUTOX* -,493,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6130;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 1;
Total Number of Employees Exposed 3,537;
Total Number of Female Employees Exposed 3,487


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HUTOX*
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

RTECS Compound Description:
   Drug
   Human Data

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