RTECS:QD1400000 The Registry of Toxic Effects of Chemical Substances

Morphinan - 6 - alpha - ol, 7,8 - didehydro - 4,5 - alpha - epoxy - 3 - methoxy - 17 - methyl - , sulfate (2:1) (salt)

RTECS #: QD1400000

CAS #: 1420-53-7

UPDATE: November 2006 MW: 694.86 MF: C₃₆H₄₂N₂O₆•O₄S

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

Codeine sulfate

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis intraperitoneal
other fish 100 mg/L BEXBBO 16,425,1980

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
subcutaneous
mouse lowest published toxic dose: 100 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Sex ratio JPMSAE 66,1727,1977

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 143 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes JPMSAE 63,451,1974
intraperitoneal
mouse lowest published toxic dose: 50 mg/kg Behavioral: Analgesia JPETAB 308,358,2004
intraperitoneal
rat lethal dose (50 percent kill): 107 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Rigidity (includes catalepsy) TXCYAC 14,217,1979
intravenous
mouse lethal dose (50 percent kill): 68 mg/kg N/R JPETAB 134,332,1961
intravenous
rat lethal dose (50 percent kill): 55 mg/kg N/R JPETAB 134,332,1961
oral
mouse lethal dose (50 percent kill): 395 mg/kg N/R JPETAB 134,332,1961
oral
rat lethal dose (50 percent kill): 430 mg/kg Behavioral: Analgesia AIPTAK 123,48,1959
subcutaneous
mouse lethal dose (50 percent kill): 183 mg/kg N/R JPETAB 134,332,1961
subcutaneous
rat lethal dose (50 percent kill): 332 mg/kg N/R JPETAB 134,332,1961

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81365;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 429
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81365;
Number of Industries 1;
Total Number of Facilities 86;
Number of Occupations 4;
Total Number of Employees Exposed 5,578;
Total Number of Female Employees Exposed 4,863

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BEXBBO Biochemistry and Experimental Biology. (Padua, Italy) V.10-16, 1971/72-80. Suspended.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a narcotic

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector

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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	intraperitoneal other fish	100 mg/L	BEXBBO 16,425,1980

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
subcutaneous mouse	lowest published toxic dose: 100 mg/kg (9 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Effects on newborn: Sex ratio	JPMSAE 66,1727,1977

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 143 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes	JPMSAE 63,451,1974
intraperitoneal mouse	lowest published toxic dose: 50 mg/kg	Behavioral: Analgesia	JPETAB 308,358,2004
intraperitoneal rat	lethal dose (50 percent kill): 107 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Behavioral: Rigidity (includes catalepsy)	TXCYAC 14,217,1979
intravenous mouse	lethal dose (50 percent kill): 68 mg/kg	N/R	JPETAB 134,332,1961
intravenous rat	lethal dose (50 percent kill): 55 mg/kg	N/R	JPETAB 134,332,1961
oral mouse	lethal dose (50 percent kill): 395 mg/kg	N/R	JPETAB 134,332,1961
oral rat	lethal dose (50 percent kill): 430 mg/kg	Behavioral: Analgesia	AIPTAK 123,48,1959
subcutaneous mouse	lethal dose (50 percent kill): 183 mg/kg	N/R	JPETAB 134,332,1961
subcutaneous rat	lethal dose (50 percent kill): 332 mg/kg	N/R	JPETAB 134,332,1961

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 81365; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 1; Total Number of Employees Exposed 429
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 81365; Number of Industries 1; Total Number of Facilities 86; Number of Occupations 4; Total Number of Employees Exposed 5,578; Total Number of Female Employees Exposed 4,863

REFERENCES:
CODEN	REFERENCE
AIPTAK	Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BEXBBO	Biochemistry and Experimental Biology. (Padua, Italy) V.10-16, 1971/72-80. Suspended.
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPMSAE	Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-