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Mithramycin

RTECS #: PZ2800000

CAS #: 18378-89-7

UPDATE: May 2009 MW: 1,085.28 MF: C52H76O24


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. A - 2371
  2. Antibiotic LA 7017
  3. Aureolic acid
  4. Aurlelic acid
  5. Mithracin
  1. Mithramycin A
  2. Mitramycin
  3. NSC 24559
  4. PA 144
  5. Plicamycin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage Bacillus subtilis 100 µmol/L PMSBA4 2,48,1971
DNA damage Escherichia coli 100 µmol/L PMSBA4 2,48,1971
DNA damage hamster ovary 20 mg/L CNREA8 45,2813,1985
DNA damage human HeLa cell 1 mg/L CNREA8 45,2813,1985
mutation in mammalian somatic cells hamster ovary 1,500 µg/L CNREA8 45,2813,1985
mutation in mammalian somatic cells human HeLa cell 40 µg/L CNREA8 45,2813,1985
mutation in mammalian somatic cells mouse embryo 15 mg/L CNREA8 45,2813,1985
other mutation test systems Bacillus subtilis 500 µg/L CHTHBK 26,309,1980
phage inhibition capacity Escherichia coli 60 mg/L ZAPOAK 8,139,1968
sperm morphology intraperitoneal
hamster 		1,250 µg/kg/5 day- continuous ENMUDM 4,231,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
unreported route
rat 		lowest published toxic dose: 2 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		85DJA5 -,95,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,090 µg/kg N/R ANTBAL 21,258,1976
intraperitoneal
rat 		lethal dose (50 percent kill): 2,500 µg/kg N/R ADTEAS 3,181,1968
intravenous
dog 		lethal dose (50 percent kill): 250 µg/kg N/R 85ERAY 2,1405,1978
intravenous
mouse 		lethal dose (50 percent kill): 350 µg/kg N/R ANTCAO 8,241,1958
intravenous
rat 		lethal dose (50 percent kill): 1,741 µg/kg N/R NCICP* -,215,1966
intravenous
rabbit 		lethal dose (50 percent kill): 250 µg/kg N/R 85ERAY 2,1405,1978
oral
human 		lowest published toxic dose: 50 µg/kg/5 day Blood: Thrombocytopenia CORTBR 127,106,1977
oral
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R 85GDA2 1,342,1980
subcutaneous
mouse 		lethal dose (50 percent kill): 2,810 µg/kg N/R ANTBAL 21,258,1976
subcutaneous
rat 		lethal dose (50 percent kill): 3,100 µg/kg N/R ANTBAL 21,258,1976
unreported route
mouse 		lowest published lethal dose: 2 mg/kg N/R ARZNAD 17,693,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published toxic dose: 2,400 mg/kg/4 week- intermittent Liver: Change in gall bladder structure or function

Blood: Hemorrhage

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		TXAPA9 11,468,1967
intravenous
monkey 		lowest published toxic dose: 2,400 mg/kg/4 week- intermittent Blood: Hemorrhage

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 11,468,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
32XPAD -,49,1975
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,117,2005
TOXICOLOGY REVIEW
HUTOX* -,439,1996
TOXICOLOGY REVIEW
HUTOX* -,439,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3731;
Number of Industries 1;
Total Number of Facilities 290;
Number of Occupations 8;
Total Number of Employees Exposed 6,594;
Total Number of Female Employees Exposed 2,796


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation


REFERENCES:

CODEN
REFERENCE
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975
85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980-
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CORTBR Clinical Orthopaedics and Related Research. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) No.26- 1963-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HUTOX*
NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co.
PMSBA4 Progress in Molecular and Subcellular Biology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1969-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-

Used as an antineoplastic agent

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

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