CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Methanearsonic acid, monosodium salt

RTECS #: PA2625000

CAS #: 2163-80-6

UPDATE: May 2009 MW: 161.96 MF: CH4AsO3•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Ansar 170
  2. Ansar 170L
  3. Ansar 529
  4. Arsonic acid, methyl - , monosodium salt
  5. Bueno
  6. Bueno 6
  7. Daconate
  8. Daconate 6
  9. Dal - E - Rad
  10. Dal - E - Rad 120
  11. Gepiron
  12. Herb - All
  13. MSMA
  14. Merge
  15. Merge 823
  16. Mesamate
  17. Mesamate - 400
  18. Mesamate - 600
  1. Mesamate concentrate
  2. Mesamate H.C.
  3. Methylarsonic acid, sodium salt
  4. Methylarsonat monosodny (Czech)
  5. Monate
  6. Monosodium acid methanearsonate
  7. Monosodium acid metharsonate
  8. Monosodium methanearsonate
  9. Monosodium methanearsonic acid
  10. Monosodium methylarsonate
  11. NCI - C60071
  12. Phyban
  13. Phyban H.C.
  14. Silvisar 550
  15. Sodium acid methanearsonate
  16. Target MSMA
  17. Trans - vert
  18. Weed 108


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		34 mg mild CIGET* -,-,1977
skin
rabbit 		54 mg open irritation test mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis mouse lymphocyte 3 gm/L MUREAV 386,279,1997
mutation in mammalian somatic cells mouse lymphocyte 4 gm/L MUREAV 386,279,1997


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >20 gm/m3 N/R FMCHA2 -,C211,1991
inhalation
rabbit 		lethal concentration (50 percent kill): >20 gm/m3/4 hour N/R FMCHA2 -,C52,1991
oral
cattle 		lethal dose (50 percent kill): 230 mg/kg N/R BECTA6 40,119,1988
oral
man 		lowest published toxic dose: 1,714 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Ear: Change in acuity

Liver: Liver function tests impaired 		CTOXAO 43,287,2005
oral
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R BECTA6 22,143,1979
oral
rat 		lethal dose (50 percent kill): 700 mg/kg N/R FMCHA2 -,C211,1991
oral
rabbit 		lethal dose (50 percent kill): 102 mg/kg Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume decreased or anuria 		BECTA6 40,119,1988
skin
rabbit 		lethal dose (50 percent kill): 2,500 mg/kg N/R FMCHA2 -,C211,1991
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 50 mg/kg N/R 30ZDA9 -,260,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
cattle 		lowest published toxic dose: 100 mg/kg/10 day- intermittent Gastrointestinal: Gastritis

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AJVRAH 33,1889,1972
oral
mouse 		lowest published toxic dose: 1,986 mg/kg/21 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 22,143,1979
oral
mouse 		lowest published toxic dose: 8,628 mg/kg/60 day- continuous Endocrine: Hypoglycemia

Blood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified) 		BECTA6 22,143,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,190,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(As)/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1796;
Number of Industries 1;
Total Number of Facilities 78;
Number of Occupations 1;
Total Number of Employees Exposed 235
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0703;
Number of Industries 1;
Total Number of Facilities 34;
Number of Occupations 1;
Total Number of Employees Exposed 136
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0703;
Number of Industries 1;
Total Number of Facilities 139;
Number of Occupations 3;
Total Number of Employees Exposed 3,472


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as a herbicide

RTECS Compound Description:
   Agricultural Chemical
   Organometallic
   Mutagen
   Human Data
   Primary Irritant

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us