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Methacrylic acid, 2,3 - epoxypropyl ester

RTECS #: OZ4375000

CAS #: 106-91-2

UPDATE: February 2006 MW: 142.17 MF: C7H10O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Propanol, 2,3 - epoxy - , methacrylate
  2. 2,3 - Epoxypropyl methacrylate
  3. 2 - ( (Methacryloxy) methyl) oxirane
  4. 2 - Propenoic acid, 2 - methyl - , oxiranylmethyl ester (9CI)
  5. Acriester G
  6. Blemmer G
  7. Blemmer GMA
  1. CP 105
  2. Glycidyl methacrylate
  3. Glycidyl alpha - methyl acrylate
  4. Light Ester G
  5. SR 379
  6. SY - Monomer G


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL moderate NTIS** OTS0543732
skin
rabbit 		500 µL/24 hour severe NTIS** OTS0543732


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+/-enzymatic activation step) MUREAV 517,187,2002
cytogenetic analysis intraperitoneal
rat 		300 mg/kg BJPCAL 6,235,1951
mutation in microorganisms Klebsiella pneumoniae 200 µmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+enzymatic activation step) MUREAV 172,105,1986
mutation in mammalian somatic cells hamster lung 200 µmol/L MUREAV 415,119,1998
morphological transform hamster embryo 900 µg/L WEYAEM 25,261,1996
other mutation test systems Escherichia coli 300 µmol/L MUREAV 231,205,1990
sister chromatid exchange hamster lung 78 µmol/L MUREAV 249,55,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rabbit 		lowest published toxic concentration: 50 ppm/6 hour (7-19 day pregnant) Reproductive: Other effects on female NTIS** OTS0558852
oral
rat 		lowest published toxic dose: 110 mg/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Stillbirth 		NTIS** OTS0558852


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 1,400 mg/m3/6 hour Lung, Thorax, or Respiration: Other changes NTIS** OTS0530684
inhalation
guinea pig 		lowest published lethal concentration: 1,400 mg/m3/6 hour Lung, Thorax, or Respiration: Other changes NTIS** OTS0530684
inhalation
rat 		lethal concentration (50 percent kill): 45 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes 		NTIS** OTS0546546
inhalation
rabbit 		lowest published lethal concentration: 1,400 mg/m3/6 hour Lung, Thorax, or Respiration: Other changes NTIS** OTS0530684
oral
guinea pig 		lethal dose (50 percent kill): 697 mg/kg N/R GISAAA 50(2),67,1985
oral
mouse 		lethal dose (50 percent kill): 390 mg/kg N/R GISAAA 50(2),67,1985
oral
rat 		lethal dose (50 percent kill): 500 mg/kg N/R WDZAEK 6,91,1992
skin
rabbit 		lethal dose (50 percent kill): 450 µL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 206 mg/m3/6 hour/26 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GWZHEW 16,1,1990
inhalation
rat 		lowest published toxic concentration: 40 ppm/6 hour/9 day- intermittent Olfaction: Deviated nasal septum

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 36(1 Pt2),331,1997
inhalation
rat 		lowest published toxic concentration: 15 ppm/6 hour/13 week- intermittent Olfaction: Deviated nasal septum NTIS** OTS0558871
inhalation
rat 		lowest published toxic concentration: 160 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0558852
inhalation
rabbit 		lowest published toxic concentration: 206 mg/m3/6 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Cardiac: EKG changes not diagnostic of above

Blood: Changes in erythrocyte (RBC) count 		GWZHEW 16,1,1990
oral
dog 		lowest published toxic dose: 4,500 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0546568
oral
rat 		lowest published toxic dose: 2,100 mg/kg/30 day- intermittent Behavioral: Food intake (animal)

Gastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Changes primarily in glomeruli 		GISAAA 50(2),67,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.24 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1341;
Number of Industries 2;
Total Number of Facilities 95;
Number of Occupations 7;
Total Number of Employees Exposed 4,002


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as monomer for polymerization
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-1092-8813
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GWZHEW Gongye Weisheng Yu Zhiyebing. Industrial Health and Occupational Diseases. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1973-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
WEYAEM Weisheng Yanjiu. Hygiene Research. (Weisheng Yanjiu Bianjibu, 29 Nanweilu, Xuanwuqu, Beijing, 100050, Peop. Rep. China) V.1- 1972

Used as monomer for polymerization

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

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