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p - Menthane, 1,8 - epoxy -

RTECS #: OS9275000

CAS #: 470-82-6

UPDATE: August 2007 MW: 154.28 MF: C10H18O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,8 - Cineol
  2. 1,8 - Cineole
  3. 1,8 - Epoxy - p - menthane
  4. 1,8 - Oxido - p - menthane
  5. 2 - Oxabicyclo (2.2.2) octane, 1,3,3 - trimethyl -
  6. Cajeputol
  1. Cineole
  2. Eucalyptol
  3. Eucalyptole
  4. Eukalyptol (Czech)
  5. NCI - C56575
  6. Terpan


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange hamster ovary 200 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 2 gm/kg (19-22 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic BCPCA6 22,543,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
guinea pig 		lowest published lethal dose: 2,250 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation 		TFAKA4 1,134,1955
intramuscular
mouse 		lethal dose (50 percent kill): 1 gm/kg N/R JSICAZ 21,342,1962
intraperitoneal
mouse 		lowest published toxic dose: 150 mg/kg Behavioral: Analgesia BPBLEO 27,910,2004
oral
rat 		lethal dose (50 percent kill): 2,480 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma 		FCTXAV 2,327,1964
oral
rat 		lowest published lethal dose: 2,400 mg/kg N/R FTRPAE 73,269,2002
rectal
rat 		lowest published toxic dose: 800 mg/kg Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		FCTOD7 42,579,2004
subcutaneous
dog 		lowest published lethal dose: 1,500 mg/kg Skin: After systemic exposure: Dermatitis, other TFAKA4 1,134,1955
subcutaneous
mouse 		lethal dose (50 percent kill): 1,070 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold 		SIZSAR 3,73,1952
subcutaneous
mouse 		lowest published toxic dose: 400 µL/kg Behavioral: Alteration of classical conditioning FCTOD7 40,1453,2002
unreported route
rat 		lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation PCJOAU 37,28,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 14 gm/kg/28 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOLED5 80,147,1995
oral
rat 		lowest published toxic dose: 16,800 mg/kg/28 day- intermittent Liver: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FTRPAE 73,269,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DPIRDU 2(4),10,1982


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 19540;
Number of Industries 11;
Total Number of Facilities 1,103;
Number of Occupations 23;
Total Number of Employees Exposed 5,213
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 19540;
Number of Industries 48;
Total Number of Facilities 4,397;
Number of Occupations 57;
Total Number of Employees Exposed 83,399;
Total Number of Female Employees Exposed 20,158


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FTRPAE Fitoterapia. (Inverni della Beffa SpA, via Ripamonti, 99, 20141 Milan, Italy) V.18- 1947-
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952-
TFAKA4 Trudy Instituta Fiziologii, Akademiya Nauk Kazakhshoi SSR. Transactions of the Institute of Physiology, Academy of Sciences of the Kazakh. SSR. (Izdatel'stvo Nauka Kazakhskoi SSR, Alma- Ata, USSR) V.1- 1955-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

FDA-over the counter drug

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Natural Product

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