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D ( - ) - Mandelonitrile - beta - D - gentiobioside

RTECS #: OO8450000

CAS #: 29883-15-6

UPDATE: December 1996 MW: 457.48 MF: C20H27NO11


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. (R) - alpha - ( (6 - O - beta - D - Glucopyranosyl - beta - D - glucopyranosyl) oxy) benzeneacetonitrile
  2. Amygdalin
  3. Amygdaloside
  4. Benzeneacetonitrile, alpha - ( (6 - O - beta - D - glucopyranosyl - beta - D - glucopyranosyl) oxy) - , (R) -
  5. D - Amygdalin
  1. D - Mandelonitrile - beta - D - glucosido - 6 - beta - D - glucoside
  2. Mandelonitrile - beta - gentiobioside
  3. NSC - 15780
  4. R - Amygdalin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
host-mediated assay mouse
Salmonella typhimurium 		250 mg/kg SCIEAS 198,625,1977


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
hamster 		lowest published toxic dose: 300 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		SCIEAS 215,1513,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published lethal dose: 100 mg/kg N/R NTIS** PB288-559
oral
infant 		lowest published lethal dose: 50 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		JAMAAP 238,482,1977
oral
monkey 		lowest published lethal dose: 167 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** PB288-559
oral
mouse 		lethal dose (50 percent kill): 443 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		YAKUD5 29,1291,1987
oral
rat 		lethal dose (50 percent kill): 405 mg/kg N/R NTIS** PB288-558


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 6 gm/kg/30 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		NTIS** PB288-558


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CTOXAO 17,85,1980


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5264;
Number of Industries 1;
Total Number of Facilities 427;
Number of Occupations 5;
Total Number of Employees Exposed 3,566;
Total Number of Female Employees Exposed 2,900


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as an antineoplastic agent

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 672-72-0
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