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Lysine, monohydrochloride, L -

RTECS #: OL5650000

CAS #: 657-27-2

UPDATE: May 2008 MW: 182.68 MF: C6H14N2O2•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Darvyl
  2. L - Lysine hydrochloride
  3. L - Lysine, monohydrochloride
  1. Lyamine
  2. Lysine hydrochloride
  3. Lysine monohydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 4,019 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		ABBIA4 58,253,1955
intravenous
dog 		lowest published toxic dose: 4,500 mg/kg Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed 		JTSCDR 31,87,2006
oral
rat 		lethal dose (50 percent kill): 10 gm/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		JPMSAE 62,49,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published toxic dose: 9,000 mg/kg/2 day- continuous Behavioral: Fluid intake

Gastrointestinal: Decreased motility or constipation

Kidney, Ureter, and Bladder: Proteinuria 		JTSCDR 31,87,2006
intravenous
dog 		lowest published toxic dose: 13,500 mg/kg/3 day- continuous Behavioral: Change in motor activity (specific assay)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		JTSCDR 31,87,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3664;
Number of Industries 4;
Total Number of Facilities 612;
Number of Occupations 19;
Total Number of Employees Exposed 5,509;
Total Number of Female Employees Exposed 1,728


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-

Used as vitamin

RTECS Compound Description:
   Drug

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