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Leucine, L -

RTECS #: OH2850000

CAS #: 61-90-5

UPDATE: May 2009 MW: 131.20 MF: C6H13NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (S) - 2 - Amino - 4 - methylpentanoic acid
  2. (S) - 2 - Amino - 4 - methylvaleric acid
  3. (S) - Leucine
  4. 2 - Amino - 4 - methylpentanoic acid
  5. L - (+) - Leucine
  6. L - Leucine
  7. L - Norvaline, 4 - methyl -
  8. L - alpha - Aminoisocaproic acid
  1. Leu
  2. Leucin (German)
  3. Leucine
  4. Norvaline, 4 - methyl -
  5. Pentanoic acid, 2 - amino - 4 - methyl - , (S) -
  6. Valeric acid, 2 - amino - 4 - methyl -
  7. alpha - Aminoisocaproic acid
  8. alpha - Amino - gamma - methylvaleric acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange human lymphocyte 10 mg/L MUREAV 372,75,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 90 mg/kg (1-6 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities 		ADTEAS 5,77,1972
intraperitoneal
rat 		lowest published toxic dose: 90 mg/kg (1-6 day pregnant) Reproductive: Specific developmental abnormalities: Body wall NATWAY 56,37,1969
intraperitoneal
rat 		lowest published toxic dose: 90 mg/kg (1-6 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		NATWAY 56,37,1969
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg (6-9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		NATWAY 56,37,1969
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg (6-9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		WIMJAD 18,34,1969
oral
rat 		lowest published toxic dose: 138 gm/kg (5-15 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		JONUAI 74,93,1961


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 5,379 mg/kg Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		ABBIA4 58,253,1955
subcutaneous
rabbit 		lowest published lethal dose: 2,620 mg/kg N/R AEXPBL 40,313,1898


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 8 gm/kg/8 day- intermittent Nutritional and Gross Metabolic: Other changes FCTOD7 42,1505,2004
oral
rat 		lowest published toxic dose: 108,000 mg/kg/12 day- intermittent Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		BJMRDK 36,1589,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81818;
Number of Industries 1;
Total Number of Facilities 53;
Number of Occupations 3;
Total Number of Employees Exposed 750
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81818;
Number of Industries 4;
Total Number of Facilities 1,037;
Number of Occupations 18;
Total Number of Employees Exposed 21,979;
Total Number of Female Employees Exposed 16,153


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951-
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HTOPA*
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913-
WIMJAD West Indian Medical Journal. (Univ. of the West Indies, Faculty of Medicine, Kingston 7, Jamaica) V.1- 1951-

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

ALT CAS #: 7005-03-0
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