CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Kinase (enzyme - activating) , strepto - , mixt. with streptococcal deoxyribonuclease

RTECS #: OB8885000

CAS #: 8048-16-6

UPDATE: September 2000 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. REFERENCES:

SYNONYMS:

  1. Stredorkinase
  2. Streptokinase streptodornase
  1. Varidase


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 312 ku/kg N/R YAKUD5 9,759,1967
intravenous
mouse 		lethal dose (50 percent kill): 4,789,000 units/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		GJMSA7 9,225,1960
oral
mouse 		lethal dose : >18,750 ku/kg N/R NIIRDN -,598,1995
oral
rat 		lethal dose : >8,000 ku/kg N/R NIIRDN -,598,1995
subcutaneous
mouse 		lethal dose (50 percent kill): 16,450,000 units/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation 		GJMSA7 9,225,1960
subcutaneous
rat 		lethal dose : >8,000 ku/kg N/R NIIRDN -,598,1995


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6090;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 2;
Total Number of Employees Exposed 1,040;
Total Number of Female Employees Exposed 506


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
GJMSA7 Gunma Journal of Medical Sciences. (Maebashi, Japan) V.1-17, 1952-69. Discontinued.
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

RTECS Compound Description:
   Drug
   Natural Product

ALT CAS #: 50922-86-6
Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  RTECS List |  Contact Us