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Isovaleric acid

RTECS #: NY1400000

CAS #: 503-74-2

UPDATE: February 2007 MW: 102.15 MF: C5H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 3 - Methylbutanoic acid
  2. 3 - Methylbutyrate
  3. 3 - Methylbutyric acid
  4. Acetic acid, isopropyl -
  5. Butyric acid, 3 - methyl -
  6. Delphinic acid
  1. Isopentanoic acid
  2. Isopropylacetic acid
  3. Isovalerianic
  4. Isovalerianic acid
  5. Kyselina isovalerova (Czech)
  6. beta - Methylbutyric acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		940 µg mild UCDS** 1/31/1972
skin
rabbit 		470 mg open irritation test moderate UCDS** 1/31/1972
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,841,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 1,000 mg/m3 Behavioral: Alteration of classical conditioning TOVEFN (6),38,2001
inhalation
mouse 		lethal concentration (50 percent kill): 5,600 mg/m3/2 hour N/R TOVEFN (6),38,2001
inhalation
rat 		lowest published toxic concentration: 584 mg/m3/4 hour Behavioral: Alteration of classical conditioning TOVEFN (6),38,2001
intravenous
mouse 		lethal dose (50 percent kill): 1,120 mg/kg Behavioral: Convulsions or effect on seizure threshold APTOA6 18,141,1961
ocular
mammal (species unspecified) 		lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TOVEFN (6),38,2001
oral
mouse 		lethal dose (50 percent kill): 1,375 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Vascular: Other changes 		TOVEFN (6),38,2001
oral
mouse 		lethal dose (50 percent kill): 1,375 mg/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance TOVEFN (6),38,2001
oral
rat 		lethal dose (50 percent kill): 2 mL/kg N/R UCDS** 1/31/1972
oral
rat 		lethal dose (50 percent kill): 1,037 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Vascular: Other changes 		TOVEFN (6),38,2001
oral
rat 		lethal dose (50 percent kill): 1,037 mg/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance TOVEFN (6),38,2001
skin
mammal (species unspecified) 		lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TOVEFN (6),38,2001
skin
mouse 		lowest published toxic dose: 100 pph/5 hour Skin: After topical application: Corrosive TOVEFN (6),38,2001
skin
rat 		lowest published toxic dose: 100 pph/5 hour Skin: After topical application: Corrosive TOVEFN (6),38,2001
skin
rabbit 		lethal dose (50 percent kill): 310 µL/kg N/R UCDS** 1/31/1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AMIHAB 21,100,1960


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84451;
Number of Industries 2;
Total Number of Facilities 35;
Number of Occupations 2;
Total Number of Employees Exposed 69
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84451;
Number of Industries 4;
Total Number of Facilities 148;
Number of Occupations 16;
Total Number of Employees Exposed 6,695;
Total Number of Female Employees Exposed 1,037


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in flavors, perfumes and manufacture of sedatives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in flavors, perfumes and manufacture of sedatives

RTECS Compound Description:
   Primary Irritant

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