CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Isophthaloyl chloride

RTECS #: NT2625000

CAS #: 99-63-8

UPDATE: February 2008 MW: 203.02 MF: C8H4Cl2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,3 - Benzenedicarbonyl chloride
  2. Dichlorid kyseliny isoftalove (Czech)
  3. Isophthalic acid chloride
  4. Isophthalic acid dichloride
  5. Isophthalyl dichloride
  1. Isophthaloyl dichloride
  2. Isophthalyl chloride
  3. m - Phthalic dichloride
  4. m - Phthaloyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		40 mg mild UCDS** 11/3/1971
skin
rabbit 		200 mg open irritation test moderate UCDS** 11/3/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 0.4 gm/m3/5 minute Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes 		TPKVAL 9,158,1967
inhalation
mouse 		lethal concentration : 0.4 gm/m3/2 hour Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Cyanosis 		TPKVAL 9,158,1967
inhalation
rat 		lethal concentration : >31 gm/m3/4 hour N/R NTIS** OTS0533736
ocular
rabbit 		lowest published toxic dose: 100 pph Eye: Lacrimation

Eye: Conjunctiva irritation

Eye: Corneal damage 		TPKVAL 9,158,1967
oral
mouse 		lethal dose (50 percent kill): 2,221 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay) 		GISAAA 47(7),75,1982
oral
rat 		lethal dose (50 percent kill): 2,200 mg/kg N/R 34ZIAG -,475,1969
oral
rabbit 		lethal dose (50 percent kill): 1,175 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay) 		GISAAA 47(7),75,1982
skin
rabbit 		lethal dose (50 percent kill): 1,410 mg/kg N/R TXAPA9 28,313,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 0.4 gm/m3/17 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 9,158,1967
inhalation
mouse 		lowest published toxic concentration: 0.4 gm/m3/45 day- intermittent Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 9,158,1967
inhalation
rat 		lowest published toxic concentration: 0.4 gm/m3/45 day- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema 		TPKVAL 9,158,1967
oral
rat 		lowest published toxic dose: 1,817 mg/kg/22 week- intermittent Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GISAAA 47(7),75,1982
oral
rat 		lowest published toxic dose: 10 gm/kg/2 week- intermittent Gastrointestinal: Alteration in gastric secretion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0533736
skin
guinea pig 		lowest published toxic dose: 10,000 mg/kg/10 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TPKVAL 9,158,1967
skin
guinea pig 		lowest published toxic dose: 7,000 mg/kg/7 day- intermittent Vascular: Other changes TPKVAL 9,158,1967
skin
rabbit 		lowest published toxic dose: 2,500 mg/kg/10 day- intermittent Skin: After topical application: Primary irritation TPKVAL 9,158,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.02 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4719;
Number of Industries 1;
Total Number of Facilities 23;
Number of Occupations 2;
Total Number of Employees Exposed 45


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as catalyst, plastics and polymer intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as catalyst, plastics and polymer intermediate

RTECS Compound Description:
   Primary Irritant

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us