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Isonipecotic acid, 1 - (3 - cyano - 3,3 - diphenylpropyl) - 4 - phenyl - , ethyl ester, hydrochloride

RTECS #: NS5300000

CAS #: 3810-80-8

UPDATE: November 2007 MW: 489.10 MF: C30H32N2O2•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. 1 - (3 - Cyano - 3,3 - diphenylpropyl) - 4 - phenylisonipecotic acid ethyl ester hydrochloride
  2. Diphenoxylate hydrochloride
  3. Ethyl 1 - (3 - cyano - 3,3 - diphenylpropyl) - 4 - phenylisonipecotate monohydrochloride
  1. R 1132
  2. R 1132 (antiperistaltic)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): >320 mg/kg N/R ARZNAD 24,1636,1974
oral
rat 		lethal dose (50 percent kill): 221 mg/kg N/R ARZNAD 24,1633,1974
subcutaneous
mouse 		lethal dose (50 percent kill): >160 mg/kg N/R ARZNAD 24,1636,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ENTOX* -,73,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3182;
Number of Industries 1;
Total Number of Facilities 105;
Number of Occupations 4;
Total Number of Employees Exposed 8,242;
Total Number of Female Employees Exposed 7,235


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005

FDA-proprietary drug

RTECS Compound Description:
   Drug

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