RTECS:NO1700000 The Registry of Toxic Effects of Chemical Substances

Ipecac syrup

RTECS #: NO1700000

CAS #: 8012-96-2

UPDATE: March 2000 MW: N/R MF: N/R

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

Cartagena ipecacuanha

Cephaelis ipecacauanha

Ipecac fluid extract

Ipecacuanha

Syrup of ipecac, U.S.P

Uragoga ipecacuanha

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
dog lowest published lethal dose: 5 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Ulceration or bleeding from small intestine

Gastrointestinal: Nausea or vomiting 36THAV -,175,1977
oral
human lowest published toxic dose: 70 mg/kg Gastrointestinal: Nausea or vomiting JPMSAE 65,1398,1976
oral
man lowest published toxic dose: 214 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Nausea or vomiting SMJOAV 77,804,1984
oral
rat lowest published lethal dose: 510 無/kg Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain YACHDS 27,891,1999
oral
woman lowest published lethal dose: 113 mg/kg/13 week- continuous Vascular: BP lowering not characterized in autonomic section

Cardiac: Change in rate

Lung, Thorax, or Respiration: Dyspnea JAMAAP 243,1927,1980

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
dog lowest published toxic dose: 420 無/kg/2 week- intermittent Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field YACHDS 27,993,1999
oral
dog lowest published toxic dose: 280 無/kg/4 week- intermittent Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting YACHDS 27,993,1999
oral
rat lowest published toxic dose: 1,400 無/kg/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field YACHDS 27,937,1999
oral
rat lowest published toxic dose: 1,400 無/kg/4 week- intermittent Behavioral: Ataxia

Kidney, Ureter, and Bladder: Urine volume increased

Nutritional and Gross Metabolic: Weight loss or decreased weight gain YACHDS 27,937,1999

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CTOXAO 10,221,1977
TOXICOLOGY REVIEW
CTOXAO 12,601,1978

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80594;
Number of Industries 3;
Total Number of Facilities 1,101;
Number of Occupations 9;
Total Number of Employees Exposed 11,391
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80594;
Number of Industries 1;
Total Number of Facilities 41;
Number of Occupations 3;
Total Number of Employees Exposed 1,098;
Total Number of Female Employees Exposed 672

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

36THAV "Management of the Poisoned Patient," Rumack, B.H., and A.R. Temple, eds., Princeton, NJ, Science Press, 1977
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

FDA-over the counter drug

RTECS Compound Description:
Human Data

ALT CAS #: 8047-07-2
ALT CAS #: 8052-61-7
ALT CAS #: 8060-27-3
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SYNONYMS:
Cartagena ipecacuanha Cephaelis ipecacauanha Ipecac fluid extract	Ipecacuanha Syrup of ipecac, U.S.P Uragoga ipecacuanha

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral dog	lowest published lethal dose: 5 gm/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Ulceration or bleeding from small intestine Gastrointestinal: Nausea or vomiting	36THAV -,175,1977
oral human	lowest published toxic dose: 70 mg/kg	Gastrointestinal: Nausea or vomiting	JPMSAE 65,1398,1976
oral man	lowest published toxic dose: 214 mg/kg	Gastrointestinal: Ulceration or bleeding from stomach Gastrointestinal: Nausea or vomiting	SMJOAV 77,804,1984
oral rat	lowest published lethal dose: 510 無/kg	Behavioral: Somnolence (general depressed activity) Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	YACHDS 27,891,1999
oral woman	lowest published lethal dose: 113 mg/kg/13 week- continuous	Vascular: BP lowering not characterized in autonomic section Cardiac: Change in rate Lung, Thorax, or Respiration: Dyspnea	JAMAAP 243,1927,1980

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral dog	lowest published toxic dose: 420 無/kg/2 week- intermittent	Gastrointestinal: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	YACHDS 27,993,1999
oral dog	lowest published toxic dose: 280 無/kg/4 week- intermittent	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting	YACHDS 27,993,1999
oral rat	lowest published toxic dose: 1,400 無/kg/2 week- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	YACHDS 27,937,1999
oral rat	lowest published toxic dose: 1,400 無/kg/4 week- intermittent	Behavioral: Ataxia Kidney, Ureter, and Bladder: Urine volume increased Nutritional and Gross Metabolic: Weight loss or decreased weight gain	YACHDS 27,937,1999

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		CTOXAO 10,221,1977
TOXICOLOGY REVIEW		CTOXAO 12,601,1978

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 80594; Number of Industries 3; Total Number of Facilities 1,101; Number of Occupations 9; Total Number of Employees Exposed 11,391
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 80594; Number of Industries 1; Total Number of Facilities 41; Number of Occupations 3; Total Number of Employees Exposed 1,098; Total Number of Female Employees Exposed 672

REFERENCES:
CODEN	REFERENCE
36THAV	"Management of the Poisoned Patient," Rumack, B.H., and A.R. Temple, eds., Princeton, NJ, Science Press, 1977
CTOXAO	Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
JAMAAP	JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JPMSAE	Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
SMJOAV	Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908-
YACHDS	Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-