RTECS:NM8912800 The Registry of Toxic Effects of Chemical Substances

Insulin protamine zinc

RTECS #: NM8912800

CAS #: 9004-17-5

UPDATE: February 2009 MW: N/R MF: N/R

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

Depo - insulin

Deposulin

Humulin N - U 100

I.P.Z.

Insulin zinc protaminate

Insulin zinc protamine

Insulin retard RI

Insulyl - retard

Isophane insulin

Isophane insulin suspension

NPH 50 insulin

NPH insulin

Protamine zinc insulin

Protamine zinc insulin injection

Protamine zinc insulin suspension

Zinc protamine insulin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
rat lowest published toxic dose: 42 international unit/kg (14-20 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Other postnatal measures or effects DBRRDB 88,127,1995
intraperitoneal
mouse lowest published toxic dose: 167 痢/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system ANREAK 124,441,1956
subcutaneous
rat lowest published toxic dose: 1,458 痢/kg (15-21 day pregnant) Reproductive: Effects on newborn: Stillbirth DIAEAZ 13,44,1964
subcutaneous
rabbit lowest published toxic dose: 13 units/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Other developmental abnormalities IJTOFN 21,181,2002

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
rat lethal dose (50 percent kill): 830 痢/kg Behavioral: Ataxia

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Body temperature decrease TXAPA9 4,631,1962
subcutaneous
dog lowest published toxic dose: 0.1 units/kg Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins BJMRDK 37,1095,2004
subcutaneous
mouse lethal dose (50 percent kill): 195 international unit/kg N/R AIPTAK 153,379,1965

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
rat lowest published toxic dose: 210 units/kg/5 week- intermittent Endocrine: Hypoglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Metabolism (intermediary): Lipids including transport PHREP* 57,610,2005
intraperitoneal
rat lowest published toxic dose: 210 units/kg/5 week- intermittent Endocrine: Hypoglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Metabolism (intermediary): Lipids including transport PHREP* 57,610,2005
subcutaneous
rat lowest published toxic dose: 510 units/kg/17 day- intermittent Behavioral: Fluid intake

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Other changes BJMRDK 34,389,2001
subcutaneous
rat : 56 units/kg/1 week- intermittent Behavioral: Food intake (animal) BPBLEO 27,338,2004
subcutaneous
rat : 112 units/kg/2 week- intermittent Endocrine: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport BPBLEO 27,338,2004
subcutaneous
rat : 672 units/kg/12 week- intermittent Eye: Other eye effects BPBLEO 27,338,2004
subcutaneous
rabbit lowest published toxic dose: 13 units/kg/13 day- intermittent Behavioral: Excitement

Endocrine: Hypoglycemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field IJTOFN 21,181,2002

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6062;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 314

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
DBRRDB Developmental Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1981-
DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
PHREP*

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a hypoglycemic agent

RTECS Compound Description:
   Drug
   Reproductive Effector
   Hormone

ALT CAS #: 8052-74-2
ALT CAS #: 8053-24-5
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SYNONYMS:
Depo - insulin Deposulin Humulin N - U 100 I.P.Z. Insulin zinc protaminate Insulin zinc protamine Insulin retard RI Insulyl - retard	Isophane insulin Isophane insulin suspension NPH 50 insulin NPH insulin Protamine zinc insulin Protamine zinc insulin injection Protamine zinc insulin suspension Zinc protamine insulin

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular rat	lowest published toxic dose: 42 international unit/kg (14-20 day pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Other postnatal measures or effects	DBRRDB 88,127,1995
intraperitoneal mouse	lowest published toxic dose: 167 痢/kg (8 day pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Musculoskeletal system	ANREAK 124,441,1956
subcutaneous rat	lowest published toxic dose: 1,458 痢/kg (15-21 day pregnant)	Reproductive: Effects on newborn: Stillbirth	DIAEAZ 13,44,1964
subcutaneous rabbit	lowest published toxic dose: 13 units/kg (6-18 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Abortion Reproductive: Other developmental abnormalities	IJTOFN 21,181,2002

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal rat	lethal dose (50 percent kill): 830 痢/kg	Behavioral: Ataxia Endocrine: Hypoglycemia Nutritional and Gross Metabolic: Body temperature decrease	TXAPA9 4,631,1962
subcutaneous dog	lowest published toxic dose: 0.1 units/kg	Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other proteins	BJMRDK 37,1095,2004
subcutaneous mouse	lethal dose (50 percent kill): 195 international unit/kg	N/R	AIPTAK 153,379,1965

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal rat	lowest published toxic dose: 210 units/kg/5 week- intermittent	Endocrine: Hypoglycemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Metabolism (intermediary): Lipids including transport	PHREP* 57,610,2005
intraperitoneal rat	lowest published toxic dose: 210 units/kg/5 week- intermittent	Endocrine: Hypoglycemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Metabolism (intermediary): Lipids including transport	PHREP* 57,610,2005
subcutaneous rat	lowest published toxic dose: 510 units/kg/17 day- intermittent	Behavioral: Fluid intake Endocrine: Hypoglycemia Nutritional and Gross Metabolic: Other changes	BJMRDK 34,389,2001
subcutaneous rat	: 56 units/kg/1 week- intermittent	Behavioral: Food intake (animal)	BPBLEO 27,338,2004
subcutaneous rat	: 112 units/kg/2 week- intermittent	Endocrine: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	BPBLEO 27,338,2004
subcutaneous rat	: 672 units/kg/12 week- intermittent	Eye: Other eye effects	BPBLEO 27,338,2004
subcutaneous rabbit	lowest published toxic dose: 13 units/kg/13 day- intermittent	Behavioral: Excitement Endocrine: Hypoglycemia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	IJTOFN 21,181,2002

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X6062; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 2; Total Number of Employees Exposed 628; Total Number of Female Employees Exposed 314

REFERENCES:
CODEN	REFERENCE
AIPTAK	Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ANREAK	Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
BJMRDK	Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
BPBLEO	Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
DBRRDB	Developmental Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1981-
DIAEAZ	Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952-
IJTOFN	International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
PHREP*
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-