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5' - Inosinic acid, disodium salt

RTECS #: NM7519500

CAS #: 4691-65-0

UPDATE: January 1997 MW: 392.20 MF: C10H11N4O8P•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 5' - Imp disodium salt
  2. Disodium IMP
  3. Disodium inosinate
  4. Disodium 5' - inosinate
  5. Disodium inosine 5' - monophosphate
  6. Disodium inosine 5' - phosphate
  1. IMP disodium salt
  2. IMP sodium salt
  3. Inosin - 5' - monophosphate disodium
  4. Inosine 5' - monophosphate disodium
  5. Sodium inosinate
  6. Sodium 5' - inosinate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 1 gm/L FCTOD7 22,623,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 250 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JJPAAZ 22,201,1972
intraperitoneal
mouse 		lowest published toxic dose: 500 mg/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death JJPAAZ 22,201,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 5,400 mg/kg N/R TIDZAH 24,553,1966
intraperitoneal
rat 		lethal dose (50 percent kill): 4,850 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		AJINO* -,-,1973
intravenous
mouse 		lethal dose (50 percent kill): 3,300 mg/kg N/R TIDZAH 24,553,1966
intravenous
rat 		lethal dose (50 percent kill): 2,730 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		AJINO* -,-,1973
oral
mouse 		lethal dose (50 percent kill): 12 gm/kg N/R TIDZAH 24,553,1966
oral
rat 		lethal dose (50 percent kill): 15,900 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		AJINO* -,-,1973
subcutaneous
mouse 		lethal dose (50 percent kill): 5,480 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		AJINO* -,-,1973
subcutaneous
rat 		lethal dose (50 percent kill): 3,900 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		AJINO* -,-,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 693 gm/kg/26 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight 		TXCYAC 2,185,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1104;
Number of Industries 4;
Total Number of Facilities 213;
Number of Occupations 6;
Total Number of Employees Exposed 3,527;
Total Number of Female Employees Exposed 1,444


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AJINO* Ajinomoto Co., Inc. (9 W. 57th St., Suite 4625, New York, NY 10019)
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
TIDZAH Tokyo Ika Daigaku Zasshi. Journal of Tokyo Medical College. (Tokyo Ika Daigaku Igakkai, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160, Japan) 1918-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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