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Indol - 5 - ol, 3 - (2 - aminoethyl) - , compd. with creatinine sulfate

RTECS #: NM2550000

CAS #: 971-74-4

UPDATE: February 2009 MW: 405.48 MF: C10H12N2O•C4H7N3O•H2O4S•H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 3 - (2 - Aminoethyl) indol - 5 - ol, creatinine sulfate
  2. 5 - HT creatinine sulfate
  3. 5 - Hydroxytryptamine creatinine sulfate
  4. 5 - Hydroxytryptamine creatinine sulfate monohydrate
  1. Creatinine, sulfate, compd. with 3 - (2 - aminoethyl) indole - 5 - ol (1:1:1) , monohydrate
  2. Creatinine, sulfate, compd. with 3 - (2 - aminoethyl) indol - 5 - ol (1:1:1)
  3. Serotin creatinine sulfate
  4. Serotonin creatinine sulfate monohydrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 10 mg/kg (4 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male 		PSEBAA 170,464,1982
intravaginal
rat 		lowest published toxic dose: 50 mg/kg (6 day pregnant) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Other measures of fertility 		JRPFA4 44,53,1975
intravenous
rat 		lowest published toxic dose: 10 mg/kg (20 day pregnant) Reproductive: Effects on newborn: Stillbirth AJPHAP 169,537,1952
parenteral
mouse 		lowest published toxic dose: 40 mg/kg (5 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) JOENAK 43,xxxiv,1969
parenteral
rat 		lowest published toxic dose: 20 mg/kg (6 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) JOENAK 43,xxxiv,1969
subcutaneous
mouse 		lowest published toxic dose: 5 mg/kg (16 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death PRGLBA 2,295,1972
subcutaneous
mouse 		lowest published toxic dose: 20 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		SCIEAS 141,717,1963
subcutaneous
mouse 		lowest published toxic dose: 20 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		SCIEAS 141,717,1963
subcutaneous
mouse 		lowest published toxic dose: 10 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Maternal- fetal exchange

Reproductive: Effects on embryo or fetus: Fetal death 		AJOGAH 99,250,1967
subcutaneous
rat 		lowest published toxic dose: 20 mg/kg (5 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Other measures of fertility 		BIREBV 29,151,1983
subcutaneous
rat 		lowest published toxic dose: 10 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear 		BJPCAL 31,494,1967
subcutaneous
rat 		lowest published toxic dose: 5 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BJPCAL 31,494,1967
subcutaneous
rat 		lowest published toxic dose: 2 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system BJPCAL 31,494,1967
subcutaneous
rat 		lowest published toxic dose: 20 mg/kg (21 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) JPBAA7 94,113,1967


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
cat 		lowest published toxic dose: 10 µg/kg Brain and Coverings: Changes in circulation

Vascular: BP lowering not characterized in autonomic section

Vascular: Other changes 		AEPPAE 369,591,2004
intraarterial
dog 		lowest published toxic dose: 0.1 µg/kg/1 minute Vascular: Measurement of regional blood flow NNAPBA 363,73,2000
intracerebral
rat 		lowest published toxic dose: 8 µg/kg Behavioral: Food intake (animal) EURNE* 12,445,2002
intracerebral
rat 		lowest published toxic dose: 8 µg/kg Endocrine: Change in LH EJPHAZ 491,77,2004
intraperitoneal
mouse 		lethal dose (50 percent kill): 405 mg/kg N/R YKKZAJ 94,1620,1974
intraperitoneal
rat 		lowest published toxic dose: 4 mg/kg Gastrointestinal: Ulceration or bleeding from stomach FATOAO 50,77,1987
intraperitoneal
rat 		lowest published toxic dose: 0.4 mg/kg Gastrointestinal: Other changes FATOAO 50,77,1987
intravenous
cat 		lowest published toxic dose: 1 µg/kg Vascular: Regional or general arteriolar constriction

Vascular: Change in plasma or blood volume 		NNAPBA 361,665,2000
intravenous
cat 		lowest published toxic dose: 10 µg/kg Brain and Coverings: Changes in circulation

Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		AEPPAE 369,591,2004
intravenous
guinea pig 		lethal dose (50 percent kill): 28 mg/kg Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma JPMSAE 57,1543,1968
intravenous
mouse 		lethal dose (50 percent kill): 352 mg/kg N/R JPETAB 105,80,1952
intravenous
rat 		lethal dose (50 percent kill): 66 mg/kg N/R JPETAB 105,80,1952
intravenous
rat 		lowest published toxic dose: 100 µg/kg/10 minute Cardiac: Pulse rate decreased with fall in BP NSAPCC 359,331,1999
intravenous
rat 		lowest published toxic dose: 30 µg/kg/10 minute Cardiac: Cardiac output

Vascular: BP lowering not characterized in autonomic section

Vascular: Measurement of regional blood flow 		NSAPCC 359,331,1999
intravenous
rat 		lowest published toxic dose: 10 µg/kg Vascular: BP lowering not characterized in autonomic section EJPHAZ 502,239,2004
intravenous
rat 		lowest published toxic dose: 30 µg/kg Cardiac: Change in rate JPHSC* 104,263,2007
subcutaneous
mouse 		lethal dose (50 percent kill): >1,997 mg/kg N/R JPETAB 105,80,1952
subcutaneous
rat 		lethal dose (50 percent kill): 257 mg/kg N/R JPETAB 105,80,1952


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3563;
Number of Industries 1;
Total Number of Facilities 10;
Number of Occupations 2;
Total Number of Employees Exposed 53;
Total Number of Female Employees Exposed 26


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EURNE* European Neuropsychopharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Nov.1990-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher information, see JPTLAS.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPHSC*
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
NNAPBA Naunyn-Schmiedebergs Archiv fuer Pharmakologie. (Berlin, Ger.) V.264-271, 1969-71. For publisher information, see NSAPCC.
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

RTECS Compound Description:
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   Mutagen
   Reproductive Effector

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