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1,3 - Indandione, 2 - diphenylacetyl -

RTECS #: NK5600000

CAS #: 82-66-6

UPDATE: May 2009 MW: 340.39 MF: C23H16O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. 2 - (Diphenylacetyl) indan - 1,3 - dione
  2. 2 - (Diphenylacetyl) - 1H - indene - 1,3 (2H) - dione
  3. 2 - Diphenylacetyl - 1,3 - diketohydrindene
  4. 2 - Diphenyl - acetyl - indan - 1,3 - dion (German)
  5. 2 - Diphenylacetyl - 1,3 - indandione
  6. Contrax - D
  7. Didandin
  8. Dipaxin
  9. Diphacin
  1. Diphacinone
  2. Diphenacin
  3. Diphenadione
  4. Kill - Ko Rat Killer
  5. Promar
  6. Promar PCQ
  7. Ramik
  8. Ratindan 1
  9. U 1363


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 2 gm/m3/4 hour N/R PEMNDP 9,310,1991
oral
cat 		lethal dose (50 percent kill): 15 mg/kg N/R PCOC** -,429,1966
oral
cat 		lethal dose (50 percent kill): 14.7 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Emphysema

Gastrointestinal: Ulceration or bleeding from large intestine 		VCVGK* -,477,1994
oral
duck 		lethal dose (50 percent kill): 3,158 mg/kg N/R PEMNDP 9,310,1991
oral
dog 		lethal dose (50 percent kill): 3 mg/kg N/R 28ZEAL 5,84,1976
oral
dog 		lethal dose (50 percent kill): 3 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Emphysema

Gastrointestinal: Ulceration or bleeding from large intestine 		VCVGK* -,477,1994
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 910 µg/kg N/R SCIEAS 177,806,1972
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 9,600 µg/kg N/R BECTA6 23,211,1979
oral
mouse 		lethal dose (50 percent kill): 28,300 µg/kg N/R NNGADV 17,S319,1992
oral
pig 		lethal dose (50 percent kill): 150 mg/kg N/R 28ZEAL 5,84,1976
oral
pig 		lethal dose (50 percent kill): 150 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Emphysema

Gastrointestinal: Ulceration or bleeding from large intestine 		VCVGK* -,477,1994
oral
rat 		lethal dose (50 percent kill): 1,500 µg/kg N/R 85DPAN -,-,1971/1976
oral
rat 		lethal dose (50 percent kill): 230 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Emphysema

Gastrointestinal: Ulceration or bleeding from large intestine 		VCVGK* -,477,1994
oral
rabbit 		lethal dose (50 percent kill): 35 mg/kg N/R PSEBAA 80,139,1952
skin
rat 		lethal dose (50 percent kill): 200 mg/kg N/R PEMNDP 9,310,1991
unreported route
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R YKYUA6 30,397,1979
unreported route
rat 		lethal dose (50 percent kill): 11 mg/kg N/R YKYUA6 30,397,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 22 mg/m3/4 hour/122 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,477,1994
inhalation
rat 		lowest published toxic concentration: 22 mg/m3/4 hour/60 day- intermittent Behavioral: Somnolence (general depressed activity)

Blood: Change in clotting factors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,477,1994
oral
mouse 		lowest published toxic dose: 6 mg/kg/4 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JWMAA9 41,298,1977
skin
rabbit 		lowest published toxic dose: 30,000 mg/kg/10 day- intermittent Blood: Changes in erythrocyte (RBC) count VCVGK* -,477,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
VHTODE 43,353,2001
TOXICOLOGY REVIEW
HUTOX* -,561,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,176,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.01 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 27610;
Number of Industries 6;
Total Number of Facilities 953;
Number of Occupations 5;
Total Number of Employees Exposed 8,704;
Total Number of Female Employees Exposed 561


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTOX*
JWMAA9 Journal of Wildlife Management. (Wildlife Soc., 5410 Grosvenor Lane, Bethesda, MD 20814) V.1- 1937-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used for control of rats, mice, voles and certain other rodents; applied in bait form

RTECS Compound Description:
   Agricultural Chemical
   Drug

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