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Imidazole, 2 - methyl -

RTECS #: NI7175000

CAS #: 693-98-1

UPDATE: May 2009 MW: 82.12 MF: C4H6N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Methylimidazole


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 58,800 mg/kg (14 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		ARTODN 80,169,2006
oral
rat 		lowest published toxic dose: 49,000 mg/kg (14 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders ARTODN 80,169,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 480 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 14,301,1969
oral
mouse 		lethal dose (50 percent kill): 1,400 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 14,301,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 54 gm/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 15,202,1995
oral
mouse 		lowest published toxic dose: 108 gm/kg/90 day- intermittent Endocrine: Evidence of thyroid hyperfunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 30,203,1996
oral
mouse 		lowest published toxic dose: 14,700 mg/kg/14 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 13,725 mg/kg/26 week- intermittent Liver: Tumors

Blood: Changes in spleen 		NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 57,645 mg/kg/26 week- intermittent Liver: Tumors

Endocrine: Changes in thyroid weight 		NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 57,645 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 27,450 mg/kg/26 week- intermittent Liver: Other changes

Endocrine: Changes in thyroid weight 		NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 231,525 mg/kg/105 week- intermittent Endocrine: Thyroid tumors

Reproductive: Other reproductive system tumors 		NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 110,250 mg/kg/105 week- intermittent Endocrine: Other changes

Blood: Changes in bone marrow not included in above 		NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 59,475 mg/kg/26 week- intermittent Liver: Tumors

Liver: Changes in liver weight

Blood: Changes in spleen 		NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 27,450 mg/kg/26 week- intermittent Liver: Other changes

Liver: Tumors 		NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 110,250 mg/kg/105 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct NTPTR* TR-516
oral
mouse 		lowest published toxic dose: 2,160 mg/kg/15 day- continuous Endocrine: Other changes ARTODN 80,169,2006
oral
mouse 		lowest published toxic dose: 7,350 mg/kg/14 week- continuous Liver: Changes in liver weight

Cardiac: Changes in heart weight 		ARTODN 80,169,2006
oral
mouse 		lowest published toxic dose: 7,350 mg/kg/14 week- continuous Endocrine: Changes in spleen weight ARTODN 80,169,2006
oral
mouse 		lowest published toxic dose: 14,700 mg/kg/14 week- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Changes in spleen 		ARTODN 80,169,2006
oral
mouse 		lowest published toxic dose: 14,700 mg/kg/14 week- continuous Endocrine: Changes in spleen weight

Blood: Normocytic anemia 		ARTODN 80,169,2006
oral
mouse 		lowest published toxic dose: 29,400 mg/kg/14 week- continuous Endocrine: Other changes

Blood: Changes in spleen 		ARTODN 80,169,2006
oral
mouse 		lowest published toxic dose: 58,800 mg/kg/14 week- continuous Cardiac: Changes in heart weight

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ARTODN 80,169,2006
oral
mouse 		lowest published toxic dose: 58,800 mg/kg/14 week- continuous Kidney, Ureter, and Bladder: Other changes

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ARTODN 80,169,2006
oral
mouse 		lowest published toxic dose: 110.250 gm/kg/105 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct TOPADD 33,313,2005
oral
mouse 		lowest published toxic dose: 231.525 gm/kg/105 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOPADD 33,313,2005
oral
rat 		lowest published toxic dose: 13,500 mg/kg/90 day- continuous Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 15,202,1995
oral
rat 		lowest published toxic dose: 11,250 mg/kg/90 day- intermittent Endocrine: Evidence of thyroid hyperfunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 30,203,1996
oral
rat 		lowest published toxic dose: 11,760 mg/kg/14 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* TR-516
oral
rat 		lowest published toxic dose: 12,740 mg/kg/14 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* TR-516
oral
rat 		lowest published toxic dose: 22,540 mg/kg/14 week- intermittent Behavioral: Food intake (animal) NTPTR* TR-516
oral
rat 		lowest published toxic dose: 2,379 mg/kg/26 week- intermittent Liver: Other changes

Blood: Microcytosis with or without anemia 		NTPTR* TR-516
oral
rat 		lowest published toxic dose: 9,150 mg/kg/26 week- intermittent Liver: Other changes

Endocrine: Other changes

Blood: Microcytosis with or without anemia 		NTPTR* TR-516
oral
rat 		lowest published toxic dose: 23,790 mg/kg/26 week- intermittent Endocrine: Thyroid tumors

Endocrine: Changes in thyroid weight 		NTPTR* TR-516
oral
rat 		lowest published toxic dose: 21,960 mg/kg/26 week- intermittent Endocrine: Changes in thyroid weight NTPTR* TR-516
oral
rat 		lowest published toxic dose: 42,090 mg/kg/26 week- intermittent Endocrine: Thyroid tumors NTPTR* TR-516
oral
rat 		lowest published toxic dose: 7,320 mg/kg/26 week- intermittent Endocrine: Other changes NTPTR* TR-516
oral
rat 		lowest published toxic dose: 29,680 mg/kg/106 week- intermittent Liver: Tumors NTPTR* TR-516
oral
rat 		lowest published toxic dose: 89,040 mg/kg/106 week- intermittent Liver: Change in gall bladder structure or function

Liver: Tumors 		NTPTR* TR-516
oral
rat 		lowest published toxic dose: 170,660 mg/kg/106 week- intermittent Blood: Changes in spleen NTPTR* TR-516
oral
rat 		lowest published toxic dose: 2,970 mg/kg/15 day- continuous Endocrine: Other changes ARTODN 80,169,2006
oral
rat 		lowest published toxic dose: 9,000 mg/kg/15 day- continuous Behavioral: Food intake (animal)

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ARTODN 80,169,2006
oral
rat 		lowest published toxic dose: 3,675 mg/kg/14 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in testicular weight 		ARTODN 80,169,2006
oral
rat 		lowest published toxic dose: 14,700 mg/kg/14 week- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Other changes 		ARTODN 80,169,2006
oral
rat 		lowest published toxic dose: 29,400 mg/kg/14 week- continuous Behavioral: Food intake (animal)

Endocrine: Evidence of thyroid hypofunction

Blood: Normocytic anemia 		ARTODN 80,169,2006
oral
rat 		lowest published toxic dose: 24,500 mg/kg/14 week- continuous Endocrine: Evidence of thyroid hypofunction

Blood: Normocytic anemia 		ARTODN 80,169,2006
oral
rat 		lowest published toxic dose: 58,800 mg/kg/14 week- continuous Endocrine: Thyroid tumors

Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ARTODN 80,169,2006
oral
rat 		lowest published toxic dose: 49,000 mg/kg/14 week- continuous Behavioral: Food intake (animal)

Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ARTODN 80,169,2006
oral
rat 		lowest published toxic dose: 29.400 gm/kg/105 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct TOPADD 33,313,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 657,84,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1324;
Number of Industries 4;
Total Number of Facilities 67;
Number of Occupations 6;
Total Number of Employees Exposed 418
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1324;
Number of Industries 11;
Total Number of Facilities 318;
Number of Occupations 22;
Total Number of Employees Exposed 7,023;
Total Number of Female Employees Exposed 3,073


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis studies; on test (two year studies), October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

Click Here for Additional Information about RTECS

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