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Imidazole - 1 - ethanol, 2 - methyl - 5 - nitro -

RTECS #: NI5600000

CAS #: 443-48-1

UPDATE: May 2009 MW: 171.18 MF: C6H9N3O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - (2 - Hydroxy - 1 - ethyl) - 2 - methyl - 5 - nitroimidazole
  2. 1 - (2 - Hydroxyethyl) - 2 - methyl - 5 - nitroimidazole
  3. 1 - (beta - Ethylol) - 2 - methyl - 5 - nitro - 3 - azapyrrole
  4. 1 - (beta - Hydroxyethyl) - 2 - methyl - 5 - nitroimidazole
  5. 1 - (beta - Oxyethyl) - 2 - methyl - 5 - nitroimidazole
  6. 1 - (hidroxyethyl) - 2 - methyl - 5 - nitro - imidazole
  7. 1 - Hydroxyethyl - 2 - methyl - 5 - nitroimidazole
  8. 2 - Methyl - 1 - (2 - hydroxyethyl) - 5 - nitroimidazole
  9. 2 - Methyl - 3 - (2 - hydroxyethyl) - 4 - nitroimidazole
  10. 2 - Methyl - 5 - nitroimidazole - 1 - ethanol
  11. Acromona
  12. Anagiardil
  13. Atrivyl
  14. Bayer 5360
  15. Bexon
  16. CONT
  17. Clont
  18. Danizol
  19. Deflamon - wirkstoff
  20. Efloran
  21. Elyzol
  22. Entizol
  23. Eumin
  24. Flagemona
  25. Flagesol
  26. Flagil
  27. Flagyl
  28. Flegyl
  29. Giatricol
  30. Gineflavir
  31. Klion
  32. MTZ
  33. Meronidal
  34. Metronidaz
  1. Metronidazol
  2. Metronidazole
  3. Metronidazolo
  4. Monagyl
  5. NIDA
  6. NSC - 50364
  7. Nalox
  8. Neo - tric
  9. Novonidazol
  10. Orvagil
  11. RP 8823
  12. SC 10295
  13. Sanatrichom
  14. Takimetol
  15. Trichazol
  16. Trichex
  17. Trichocide
  18. Trichomol
  19. Trichomonacid 'pharmachim'
  20. Trichopal
  21. Trichopol
  22. Tricocet
  23. Tricom
  24. Tricowas B
  25. Trikacide
  26. Trikamon
  27. Trikojol
  28. Trikozol
  29. Trimeks
  30. Trivazol
  31. Vagilen
  32. Vagimid
  33. Vertisal


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		0.75% CODEDG 135,93,1999
skin
human 		0.75%/3 week- continuous mild JAADDB 50,P11,2004


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay human
Salmonella typhimurium 		10 mg/kg MUREAV 77,357,1980
body fluid assay rat
Salmonella typhimurium 		800 mg/kg MUREAV 97,171,1982
body fluid assay rat
Salmonella typhimurium 		100 mg/kg BSIBAC 61,1595,1985
cytogenetic analysis hamster lung 10 mmol/L MUREAV 78,201,1980
cytogenetic analysis unreported route
human 		86 mg/kg/30 day LANCAO 2,802,1976
cytogenetic analysis human lymphocyte 500 mg/L ENMUDM 6,467,1984
cytogenetic analysis oral
human 		250 mg/kg/10 day- continuous MUREAV 370,75,1996
cytogenetic analysis oral
mouse 		1,200 mg/kg IJEBA6 25,240,1987
cytogenetic analysis oral
mouse 		7,000 mg/kg/14 day- intermittent BCLPT* 94,226,2004
DNA adduct Escherichia coli 2 µmol MOPMA3 13,872,1977
DNA adduct mammal (species unspecified) lymphocyte 60 µmol/L MOPMA3 13,872,1977
DNA damage oral
human 		214.3 mg/kg/10 day MUREAV 478,153,2001
DNA damage human lymphocyte 10 mg/L/30 minute TOLED5 132,109,2002
DNA damage mouse lymphocyte 30 mmol/L/4 hour- continuous BJCAAI 40,94,1979
DNA damage mouse fibroblast 300 µmol/L BJCSB5 3,124,1978
DNA damage rat liver 3 mmol/L SinJF# 26OCT1982
DNA inhibition hamster lung 1 mmol/L/6 day- continuous BJCAAI 40,94,1979
DNA inhibition mouse lymphocyte 30 mmol/L/1 hour- continuous BJCAAI 40,94,1979
DNA inhibition mouse other cell types 100 mg/L ONCODU 19,183,1980
DNA inhibition other microorganisms 1 mg/L BCPCA6 23,1421,1974
DNA inhibition other microorganisms 5 mg/L BCPCA6 23,1421,1974
DNA repair Bacillus subtilis 200 µg/disc MUREAV 97,1,1982
DNA repair Escherichia coli 200 µg/disc MUREAV 97,1,1982
host-mediated assay hamster
embryo 		200 mg/kg MUREAV 190,289,1987
host-mediated assay mouse
Salmonella typhimurium 		400 mg/kg/5 day SCIEAS 188,1118,1975
host-mediated assay mouse
Escherichia coli 		4 mg/kg/2 hour MUREAV 164,9,1986
host-mediated assay mouse
Saccharomyes cerevisiae 		25 mmol/kg DECRDP 11,755,1985
mutation in microorganisms Escherichia coli 100 µmol/L (-enzymatic activation step) JEPTDQ 2(3),657,1979
mutation in microorganisms Escherichia coli 1 gm/L (+enzymatic activation step) BJCSB5 3,124,1978
mutation in microorganisms Klebsiella pneumoniae 20 µmol/L/20 hour (-enzymatic activation step) MUREAV 66,207,1979
mutation in microorganisms Neurospora crassa 8,800 mg/L (-enzymatic activation step) JEPTDQ 2(4),1109,1979
mutation in microorganisms other microorganisms 25 µmol/L (-enzymatic activation step) MUREAV 26,483,1974
mutation in microorganisms Salmonella typhimurium 25 µg/plate (+enzymatic activation step) MUREAV 38,203,1976
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) EJMCA5 25,241,1990
mutation in microorganisms Salmonella typhimurium 156 µg/plate/20 minute (-enzymatic activation step) MUTAEX 20,217,2005
mutation in microorganisms Salmonella typhimurium 156 µg/plate/20 minute (+enzymatic activation step) MUTAEX 20,217,2005
mutation in microorganisms Salmonella typhimurium 156 µg/plate/48 hour (+enzymatic activation step) MUTAEX 20,217,2005
micronucleus test oral
mouse 		7,000 mg/kg/14 day- intermittent BCLPT* 94,226,2004
micronucleus test intravaginal
rat 		100 mg/kg/5 day- intermittent EMMUEG 47,352,2006
other mutation test systems Escherichia coli 4 mg/L MUREAV 187,55,1987
other mutation test systems other microorganisms 5 mg/L BCPCA6 23,1421,1974
phage inhibition capacity Escherichia coli 500 µg/plate AMPOAX 34,111,1985
sister chromatid exchange oral
hamster 		125 mg/kg BLFSBY 29B,613,1984
sister chromatid exchange human lymphocyte 10 µg/kg/20 minute DCTODJ 1,85,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 60 mg/kg (8-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities 		TOLED5 19,37,1983
intraperitoneal
rat 		lowest published toxic dose: 1,750 mg/kg (7 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TCMUD8 21,197,2001
oral
mouse 		lowest published toxic dose: 7,000 mg/kg (14 day male) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic 		BCLPT* 94,226,2004
oral
rat 		lowest published toxic dose: 16,800 mg/kg (42 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) FAATDF 12,386,1989
oral
rat 		lowest published toxic dose: 22,400 mg/kg (56 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		FAATDF 12,386,1989
unreported route
rat 		lowest published toxic dose: 750 mg/kg (30 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina RPHRA6 20,395,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 181 gm/kg/72 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease 		JNCIAM 48,721,1972
oral
mouse 		toxic dose : 8 gm/kg/14 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease 		TUMOAB 69,379,1983
oral
mouse 		toxic dose : 21,800 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		JCROD7 112,135,1986
oral
mouse 		toxic dose : 1,680 mg/kg (1-21 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors 		JCROD7 112,135,1986
oral
rat 		lowest published toxic dose: 219 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		JJIND8 63,863,1979
oral
rat 		toxic dose : 27 gm/kg/35 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		JNCIAM 51,403,1973
oral
rat 		toxic dose : 3 gm/kg/14 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		TUMOAB 70,307,1984


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 492 mg/kg N/R TOVEFN (1),14,2001
intraperitoneal
mouse 		lethal dose (50 percent kill): 870 mg/kg N/R PJPPAA 42,471,1990
intravenous
woman 		lowest published toxic dose: 100 mg/kg/5 day- intermittent Behavioral: Hallucinations, distorted perceptions

Behavioral: Toxic psychosis

Behavioral: Irritability 		AJPSAO 154,1169,1997
oral
human 		lowest published toxic dose: 39,600 mg/kg/4 week- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Taste: Change in function

Behavioral: Headache 		CPHRDE 19,83,1999
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 2,074 mg/kg N/R TOVEFN (1),14,2001
oral
man 		lowest published toxic dose: 3,570 µg/kg/ day Liver: Jaundice, other or unclassified

Liver: Other changes

Nutritional and Gross Metabolic: Body temperature increase 		JAMAAP 193,1128,1965
oral
man 		lowest published toxic dose: 1,030 mg/kg/8 week Peripheral Nerve and Sensation: Paresthesia

Peripheral Nerve and Sensation: Structural change in nerve or sheath 		BMJOAE 2,610,1977
oral
mouse 		lethal dose (50 percent kill): 3,800 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases JMCMAR 20,1522,1977
oral
rat 		lethal dose (50 percent kill): 3 gm/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease 		OYYAA2 8,1089,1974
oral
rat 		lowest published toxic dose: 2,500 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight 		REPTED 6,491,1992
oral
woman 		lowest published toxic dose: 40 mg/kg Behavioral: Hallucinations, distorted perceptions SMJOAV 78,627,1985
oral
woman 		lowest published toxic dose: 12 mg/kg Eye: Other eye effects

Behavioral: Tremor 		BMJOAE 292,174,1986
subcutaneous
mouse 		lethal dose (50 percent kill): 3,640 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		OYYAA2 8,1089,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 910 mg/kg/7 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 23,246,2007
oral
dog 		lowest published toxic dose: 6,500 mg/kg/26 day- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		ARZNAD 28,612,1978
oral
mouse 		lowest published toxic dose: 7,000 mg/kg/14 day- intermittent Blood: Normocytic anemia

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight 		BCLPT* 94,226,2004
oral
rat 		lowest published toxic dose: 34 gm/kg/34 day- continuous Kidney, Ureter, and Bladder: Hematuria

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in testicular weight 		OYYAA2 8,1089,1974
oral
woman 		lowest published toxic dose: 85.8 mg/kg/14 day- intermittent Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes 		NEJMAG 342,534,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 13,113,1977
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,250,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,250,1987
TOXICOLOGY REVIEW
JACHDX 3,205,1977
TOXICOLOGY REVIEW
ADCMAZ 3,39,1968
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
MUREAV 613,17,2006
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,103,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
HUTOX* -,429,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,265,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4277;
Number of Industries 1;
Total Number of Facilities 216;
Number of Occupations 4;
Total Number of Employees Exposed 5,262;
Total Number of Female Employees Exposed 2,655


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; N crassa-forward mutation
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA GENETOX PROGRAM 1988, Negative: Mammalian micronucleus; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as a drug for the treatment of alcoholism and acne rosacea
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
ADCMAZ Advances in Chemotherapy. (New York, NY) V.1-3, 1964-68. For publisher information, see AVPCAQ.
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921-
AMPOAX Acta Microbiologica Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1-17(4), 1952-68; V.25- 1976-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJCSB5 British Journal of Cancer, Supplement. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2ZS, UK) No.1- 1973-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CPHRDE International Journal of Clinical Pharmacology Research. (Bioscience Ediprint Inc., 16 Rue A. - Gavard, 1227 Carouge - Geneva, Switzerland) V.1- 1981-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTOX*
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
ONCODU Revista de Chirurgui, Oncologie, Radiologie, ORL, Oftalmologie, Stomatologie, Seria: Oncologia. (Rompresfilatelia, POB 12-201, Bucharest, Romania) V.13(4)- 1974-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RPHRA6 Recent Progress In Hormone Research. Proceedings of the Laurentian Hormone Conference. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1947-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan, Italy) V.1- 1911-

Used as a drug for the treatment of alcoholism and acne rosacea

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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