RTECS:NI4770000 The Registry of Toxic Effects of Chemical Substances

Imidazole, 1 - (2,4 - dichloro - beta - ( (2,4 - dichlorobenzyl) oxy) phenethyl) -

RTECS #: NI4770000

CAS #: 22916-47-8

UPDATE: August 2007 MW: 416.14 MF: C₁₈H₁₄Cl₄N₂O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

1H - Imidazole, 1 - (2 - (2,4 - dichlorophenyl) - 2 - ( (2,4 - dichlorophenyl) methoxy) ethyl) - (9CI)

Imidazole, 1 - (2 - (2,4 - dichlorophenyl) - 2 - ( (2,4 - dichlorophenyl) methoxy) ethyl) - (9CI)

MJR 1762

Miconasole

Miconazole

R 18134

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
sex chromosome loss and nondisjunction Aspergillus nidulans 4,160 痢/L MUREAV 79,169,1980

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 800 mg/kg (15-22 day pregnant) Reproductive: Maternal effects: Parturition TJADAB 32,30A,1985
oral
rabbit lowest published toxic dose: 3,100 mg/kg (1-31 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) DRUGAY 19,7,1980

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 220 mg/kg N/R DCTODJ 13,195,1990
intraperitoneal
rat lethal dose (50 percent kill): 349 mg/kg Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation ARZNAD 31,2145,1981
intraperitoneal
rat lethal dose (50 percent kill): 1,185 mg/kg N/R USXXAM #5135943
intravenous
dog lethal dose (50 percent kill): 60 mg/kg Cardiac: Other changes DRUGAY 19,7,1980
intravenous
infant lowest published toxic dose: 104 mg/kg/4 day- intermittent Behavioral: Convulsions or effect on seizure threshold MJAUAJ 146,57,1987
intravenous
mammal (species unspecified) lethal dose (50 percent kill): 100 mg/kg Cardiac: Other changes DRUGAY 19,7,1980
intravenous
mouse lethal dose (50 percent kill): 80 mg/kg N/R BAXXDU #2067993
intravenous
rat lethal dose (50 percent kill): 105 mg/kg N/R NIIRDN -,1146,1990
intravenous
rat lowest published toxic dose: 0.65 mg/kg Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes CEXPB9 27,581,2000
oral
mouse lethal dose (50 percent kill): 519 mg/kg N/R NIIRDN -,1325,1995
oral
rat lethal dose (50 percent kill): 550 mg/kg N/R NIIRDN -,1325,1995
subcutaneous
mouse lethal dose (50 percent kill): >5,000 mg/kg N/R USXXAM #5135943
subcutaneous
rat lethal dose (50 percent kill): >5,000 mg/kg N/R USXXAM #5135943

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 900 mg/kg/6 week- intermittent Tumorigenic: Active as anti-cancer agent TXAPA9 180,22,2002

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
PBPSDY 2,333,1979
TOXICOLOGY REVIEW
TOLED5 142,207,2003
TOXICOLOGY REVIEW
BPCEM* 17,237,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4278;
Number of Industries 1;
Total Number of Facilities 46;
Number of Occupations 3;
Total Number of Employees Exposed 8,954;
Total Number of Female Employees Exposed 7,689

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971-
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 75319-47-0
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SYNONYMS:
1H - Imidazole, 1 - (2 - (2,4 - dichlorophenyl) - 2 - ( (2,4 - dichlorophenyl) methoxy) ethyl) - (9CI) Imidazole, 1 - (2 - (2,4 - dichlorophenyl) - 2 - ( (2,4 - dichlorophenyl) methoxy) ethyl) - (9CI) MJR 1762	Miconasole Miconazole R 18134

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
sex chromosome loss and nondisjunction	Aspergillus nidulans	4,160 痢/L	MUREAV 79,169,1980

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 800 mg/kg (15-22 day pregnant)	Reproductive: Maternal effects: Parturition	TJADAB 32,30A,1985
oral rabbit	lowest published toxic dose: 3,100 mg/kg (1-31 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	DRUGAY 19,7,1980

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 220 mg/kg	N/R	DCTODJ 13,195,1990
intraperitoneal rat	lethal dose (50 percent kill): 349 mg/kg	Eye: Other eye effects Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation	ARZNAD 31,2145,1981
intraperitoneal rat	lethal dose (50 percent kill): 1,185 mg/kg	N/R	USXXAM #5135943
intravenous dog	lethal dose (50 percent kill): 60 mg/kg	Cardiac: Other changes	DRUGAY 19,7,1980
intravenous infant	lowest published toxic dose: 104 mg/kg/4 day- intermittent	Behavioral: Convulsions or effect on seizure threshold	MJAUAJ 146,57,1987
intravenous mammal (species unspecified)	lethal dose (50 percent kill): 100 mg/kg	Cardiac: Other changes	DRUGAY 19,7,1980
intravenous mouse	lethal dose (50 percent kill): 80 mg/kg	N/R	BAXXDU #2067993
intravenous rat	lethal dose (50 percent kill): 105 mg/kg	N/R	NIIRDN -,1146,1990
intravenous rat	lowest published toxic dose: 0.65 mg/kg	Kidney, Ureter, and Bladder: Urine volume increased Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Other changes	CEXPB9 27,581,2000
oral mouse	lethal dose (50 percent kill): 519 mg/kg	N/R	NIIRDN -,1325,1995
oral rat	lethal dose (50 percent kill): 550 mg/kg	N/R	NIIRDN -,1325,1995
subcutaneous mouse	lethal dose (50 percent kill): >5,000 mg/kg	N/R	USXXAM #5135943
subcutaneous rat	lethal dose (50 percent kill): >5,000 mg/kg	N/R	USXXAM #5135943

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published toxic dose: 900 mg/kg/6 week- intermittent	Tumorigenic: Active as anti-cancer agent	TXAPA9 180,22,2002

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		PBPSDY 2,333,1979
TOXICOLOGY REVIEW		TOLED5 142,207,2003
TOXICOLOGY REVIEW		BPCEM* 17,237,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X4278; Number of Industries 1; Total Number of Facilities 46; Number of Occupations 3; Total Number of Employees Exposed 8,954; Total Number of Female Employees Exposed 7,689

REFERENCES:
CODEN	REFERENCE
ARZNAD	Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BAXXDU	British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
BPCEM*	Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CEXPB9	Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
DCTODJ	Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DRUGAY	Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971-
MJAUAJ	Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN	Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PBPSDY	Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977-
TJADAB	Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
USXXAM	United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)