CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Hydroxylamine, N,N - diethyl -

RTECS #: NC3500000

CAS #: 3710-84-7

UPDATE: February 2006 MW: 89.16 MF: C4H11NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Diethylhydroxylamine
  2. Ethanamine, N - ethyl - N - hydroxy - (9CI)
  3. N,N - Diethylhydroxyamine
  1. N,N - Diethylhydroxylamine
  2. N - Hydroxydiethylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test parenteral
rat 		180 mg/kg CAES** 492-78,1978
unscheduled DNA synthesis human leukocyte 4,000 ppm ENVRAL 20,99,1979
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		200 ppm CAES** 492-78,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
parenteral
rat 		lowest published toxic dose: 180 mg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) ENVRAL 20,99,1979
parenteral
rat 		lowest published toxic dose: 18 mg/kg (1 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ENVRAL 20,99,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 1,750 mg/kg N/R 34ZIAG -,217,1969
oral
mouse 		lethal dose (80 percent kill): 2,150 mg/kg N/R 34ZIAG -,217,1969
oral
rat 		lowest published lethal dose: 1,600 mg/kg N/R KODAK* 21MAY1971
skin
guinea pig 		lethal dose (50 percent kill): 100 µL/kg N/R KODAK* 21MAY1971
skin
rat 		lowest published lethal dose: 100 mg/kg N/R KODAK* 21MAY1971
skin
rabbit 		lowest published lethal dose: 2 gm/kg N/R 34ZIAG -,217,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 6 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83719;
Number of Industries 1;
Total Number of Facilities 62;
Number of Occupations 10;
Total Number of Employees Exposed 6,533
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83719;
Number of Industries 5;
Total Number of Facilities 162;
Number of Occupations 5;
Total Number of Employees Exposed 950;
Total Number of Female Employees Exposed 14


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
CAES** Reports Supported by the Pennwalt Corp. and the Center for Air Environment Studies at the Pennsylvania State University
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us