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Hydrocupreine, O - ethyl - , hydrochloride

RTECS #: MW6300000

CAS #: 3413-58-9

UPDATE: April 1995 MW: 376.97 MF: C21H28N2O2•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. REFERENCES:

SYNONYMS:

  1. Ethylhydrocupreine hydrochloride
  2. Hydrocupreine, ethyl ester, hydrochloride
  3. Neumolisina
  4. Numoquin hydrochloride
  1. Optochin hydrochloride
  2. Optoquinhydrochloride
  3. Rhombic


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
man 		lowest published toxic dose: 31 mg/kg/3 day Eye: Visual field changes

Vascular: Regional or general arteriolar constriction 		JPETAB 8,53,1916
subcutaneous
mouse 		lowest published lethal dose: 500 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes 		JPETAB 8,53,1916
unreported route
frog 		lowest published lethal dose: 300 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		JPETAB 8,53,1916


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5575;
Number of Industries 1;
Total Number of Facilities 90;
Number of Occupations 2;
Total Number of Employees Exposed 557;
Total Number of Female Employees Exposed 502


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

Used as an antiseptic

RTECS Compound Description:
   Drug
   Human Data

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