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Hydrocupreine, O - ethyl - , hydrochloride

RTECS #: MW6300000

CAS #: 3413-58-9

UPDATE: April 1995 MW: 376.97 MF: C₂₁H₂₈N₂O₂•ClH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

Ethylhydrocupreine hydrochloride

Hydrocupreine, ethyl ester, hydrochloride

Neumolisina

Numoquin hydrochloride

Optochin hydrochloride

Optoquinhydrochloride

Rhombic

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intravenous
man lowest published toxic dose: 31 mg/kg/3 day Eye: Visual field changes

Vascular: Regional or general arteriolar constriction JPETAB 8,53,1916
subcutaneous
mouse lowest published lethal dose: 500 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes JPETAB 8,53,1916
unreported route
frog lowest published lethal dose: 300 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression JPETAB 8,53,1916

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5575;
Number of Industries 1;
Total Number of Facilities 90;
Number of Occupations 2;
Total Number of Employees Exposed 557;
Total Number of Female Employees Exposed 502

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

Used as an antiseptic

RTECS Compound Description:
Drug
Human Data

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