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Hydrazine, phenyl - , hydrochloride

RTECS #: MV9000000

CAS #: 59-88-1

UPDATE: May 2008 MW: 144.62 MF: C6H8N2•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Hydrazine, phenyl - , monohydrochloride (9CI)
  2. Phenylhydrazine hydrochloride
  3. Phenylhydrazine monohydrochloride
  1. Phenylhydrazin hydrochlorid (German)
  2. Phenylhydrazinium chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair mouse liver 10 µmol/L JJCREP 79,204,1988
DNA repair rat liver 10 µmol/L JJCREP 79,204,1988
mutation in microorganisms Salmonella typhimurium 800 µg/plate (+/-enzymatic activation step) NEZAAQ 33,474,1978
mutation in microorganisms Salmonella typhimurium 252 µg/plate/72 hour (+enzymatic activation step) MUTAEX 15,495,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg (17-19 day pregnant) Reproductive: Effects on newborn: Behavioral SEIJBO 14,95,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 464 mg/kg/8 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JNCIAM 42,337,1969
oral
mouse 		lowest published toxic dose: 8,000 mg/kg/42 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		34ZRA9 -,869,1965
oral
mouse 		toxic dose : 10 gm/kg/58 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Vascular: Tumors

Blood: Lymphoma including Hodgkin's disease 		ZKKOBW 87,267,1976
oral
mouse 		toxic dose : 928 mg/kg/8 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JNCIAM 42,337,1969


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 161 mg/kg N/R ABMGAJ 18,617,1967
intravenous
mouse 		lethal dose (50 percent kill): 900 µg/kg N/R QJDRAZ 9,1455,1969
oral
mouse 		lethal dose (50 percent kill): 2,100 mg/kg N/R QJDRAZ 9,1455,1969
oral
rabbit 		lowest published lethal dose: 25 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
mouse 		lethal dose (50 percent kill): 89 mg/kg N/R FRPSAX 9,274,1954
subcutaneous
rabbit 		lowest published lethal dose: 25 mg/kg N/R HBAMAK 4,1289,1935
skin
rabbit 		lowest published lethal dose: 500 mg/kg Lung, Thorax, or Respiration: Cyanosis

Skin: After topical application: Corrosive

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 8,583,1987


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDRAZINES-air Carcinogen ceiling concentration 0.03 ppm/120 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81928;
Number of Industries 2;
Total Number of Facilities 115;
Number of Occupations 5;
Total Number of Employees Exposed 1,708
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81928;
Number of Industries 3;
Total Number of Facilities 63;
Number of Occupations 4;
Total Number of Employees Exposed 645;
Total Number of Female Employees Exposed 445


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZRA9 "Proceedings of the Quadrennial Conference on Cancer, 3rd, 1965," Severi, L., ed., Perugia, Italy, Univ. of Perugia, 1966
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands) V.1-19, 1961-81. For publisher information, see IJCREE.
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7.
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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