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1,2,6 - Hexanetriol

RTECS #: MO4650000

CAS #: 106-69-4

UPDATE: June 1998 MW: 134.20 MF: C6H14O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 1,2,6 - Trihydroxyhexane
  2. Hexane - 1,2,6 - triol
  1. Hexanetriol - 1,2,6


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		555 mg open irritation test mild UCDS** 7/13/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 10 gm/kg Gastrointestinal: Changes in structure or function of exocrine pancreas

Liver: Other changes 		TXAPA9 15,282,1969
intravenous
rat 		lethal dose (50 percent kill): 5,600 mg/kg Gastrointestinal: Changes in structure or function of exocrine pancreas

Liver: Other changes 		TXAPA9 15,282,1969
oral
mouse 		lethal dose (50 percent kill): 11,400 mg/kg N/R SCCUR* -,5,1961
oral
rat 		lethal dose (50 percent kill): 15,500 mg/kg N/R 34ZIAG -,731,1969
subcutaneous
mouse 		lethal dose (50 percent kill): 5,800 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation 		SKIZAB 28,276,1972
subcutaneous
rat 		lethal dose (50 percent kill): 10,900 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation 		SKIZAB 28,276,1972
skin
rabbit 		lethal dose (50 percent kill): >20 mL/kg N/R UCDS** 7/13/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83569;
Number of Industries 9;
Total Number of Facilities 1,530;
Number of Occupations 10;
Total Number of Employees Exposed 9,278
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83569;
Number of Industries 6;
Total Number of Facilities 207;
Number of Occupations 6;
Total Number of Employees Exposed 8,973;
Total Number of Female Employees Exposed 7,703


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
SKIZAB Shikoku Igaku Zasshi. Shikoku Medical Journal. (Tokushima Igakkai, Tokushima Daigaku Igakubu, Kuramoto-cho, Tokushima 770, Japan) V.1- 1950-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

RTECS Compound Description:
   Primary Irritant

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