The Registry of Toxic Effects of Chemical Substances

Guar gum

RTECS #: MG0185000

CAS #: 9000-30-0

UPDATE: February 2003 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1212A
  2. A - 20D
  3. Burtonite V - 7 - E
  4. Cyamopsis gum
  5. Dealca TP1
  6. Dealca TP2
  7. Decorpa
  8. Galactasol
  9. Gendriv 162
  10. Guar
  11. Guar flour
  12. Guaran
  13. Gum cyamopsis
  14. Gum guar
  15. Indalca AG
  16. Indalca AG - BV
  17. Indalca AG - HV
  1. J 2Fp
  2. Jaguar
  3. Jaguar 6000
  4. Jaguar A 20 B
  5. Jaguar A 20D
  6. Jaguar A 40F
  7. Jaguar gum A - 20 - D
  8. Jaguar No.124
  9. Jaguar plus
  10. Lycoid DR
  11. NCI - C50395
  12. Regonol
  13. Rein guarin
  14. Supercol G.F.
  15. Supercol U powder
  16. Syngum D 46D
  17. Uni - Guar


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,081,500 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Brain and Coverings: Tumors 		NTIS** PB82-202813
oral
rat 		lowest published toxic dose: 901,250 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors 		NTIS** PB82-202813


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
hamster 		lethal dose (50 percent kill): 6 gm/kg N/R FDRLI* 124,-,1976
oral
mouse 		lethal dose (50 percent kill): 8,100 mg/kg N/R FDRLI* 124,-,1976
oral
rat 		lethal dose (50 percent kill): 6,770 mg/kg N/R FCTXAV 19,287,1981
oral
rabbit 		lethal dose (50 percent kill): 7 gm/kg N/R FDRLI* 124,-,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,092 gm/kg/13 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-229,1982
oral
mouse 		lowest published toxic dose: 2,163,000 mg/kg/103 week- continuous Liver: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB82-202813
oral
rat 		lowest published toxic dose: 228 gm/kg/13 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-229,1982
oral
rat 		lowest published toxic dose: 451 gm/kg/91 day- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTXAV 19,287,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83111;
Number of Industries 10;
Total Number of Facilities 208;
Number of Occupations 20;
Total Number of Employees Exposed 3,024
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83111;
Number of Industries 20;
Total Number of Facilities 2,264;
Number of Occupations 41;
Total Number of Employees Exposed 44,736;
Total Number of Female Employees Exposed 6,883


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a food and feed additive, flavor, packaging material, cosmetic, perfume ingredient
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FDRLI* Food & Drug Research Laboratories, Inc., Papers. (P.O. Box 107, Rt. 17C, Waverly, NY 14892-0107)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used as a food and feed additive, flavor, packaging material, cosmetic, perfume ingredient

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 57406-68-5
ALT CAS #: 57406-71-0
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